INT299783

Context Info Confidence 0.3651028500 First Reported 2005 Last Reported 2010 Negated 0 Speculated 0 Reported most in NULL Documents 7 Total Number 8

plasma membrane (Cd28)

Anatomy Mention Frequency T cell 2 macrophages 1 B cells 1 dendritic cells 1 Cd28 (Mus musculus) Cd80 (Mus musculus)

Pain Term Frequency Confidence Heat abatacept 242 88.52 Infliximab 2 82.36 Inflammation 8 68.76 corticosteroid 12 5 methotrexate 42 5 cytokine 32 5 withdrawal 6 5 Pain 6 5 Etanercept 18 5 tolerance 28 5 |

Disease Term Frequency Confidence Heat Arthropathy 8 69.88 INFLAMMATION 8 68.76 Apoptosis 12 63.12 Death 6 61.92 Demyelinating Disease 6 5 Necrosis 12 5 Staphylococcus Infection 6 5 Mycobacterial Infection 2 5 Systemic Lupus Erythematosus 12 5 Pressure And Volume Under Development 18 5

Sentences Mentioned In

Key:

Protein

Event

Anatomy

Negation

Speculation

Pain term

In addition to the CD80/86-CD28 interaction, co-stimulation of T cell responses occurs through the CD40-CD154 interaction between APCs and T cells.

CD28 Binding (interaction) of CD80 in T cell

1) Confidence 0.140812717444618 Published 2010 Journal N/A Section N/A Doc Link PMC2875641

In addition to the CD80/86-CD28 interaction, co-stimulation of T cell responses occurs through the CD40-CD154 interaction between APCs and T cells.

CD28 Binding (interaction) of CD80 in T cell

2) Confidence 0.140812717444618 Published 2010 Journal N/A Section N/A Doc Link PMC2875641

These observations suggest that CD28–CD80/86 interactions are important in the initiation of the arthritis.

CD28 Binding (interactions) of CD80

3) Confidence 0.083477425726812 Published 2005 Journal N/A Section N/A Doc Link PMC2833980

These observations suggest that CD28–CD80/86 interactions are important in the initiation of the arthritis.

CD28 Binding (interactions) of CD80

4) Confidence 0.083477425726812 Published 2005 Journal N/A Section N/A Doc Link PMC2833980

The regulatory effects of interrupting CD28 interactions with CD80/86 have been harnessed in recombinant molecules (CTLA4–immunoglobulin [Ig]) that combine the extracellular domain of human CTLA4 with a portion of the Fc domain of IgG1 [10].

CD28 Binding (interactions) of CD80

5) Confidence 0.083477425726812 Published 2005 Journal N/A Section N/A Doc Link PMC2833980

CD28 is present on most T cells and it binds to both CD80 (B7-1) and CD86 (B7-2), which are present on antigen-presenting cells, including dendritic cells, B cells, and macrophages.

CD28 Binding (binds) of CD80 in dendritic cells

6) Confidence 0.083477425726812 Published 2005 Journal N/A Section N/A Doc Link PMC2833980

CD28 is present on most T cells and it binds to both CD80 (B7-1) and CD86 (B7-2), which are present on antigen-presenting cells, including dendritic cells, B cells, and macrophages.

CD28 Binding (binds) of CD80 in macrophages

7) Confidence 0.0283823247471161 Published 2005 Journal N/A Section N/A Doc Link PMC2833980

CD28 is present on most T cells and it binds to both CD80 (B7-1) and CD86 (B7-2), which are present on antigen-presenting cells, including dendritic cells, B cells, and macrophages.

CD28 Binding (binds) of CD80 in B cells

8) Confidence 0.0283823247471161 Published 2005 Journal N/A Section N/A Doc Link PMC2833980

General Comments

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