INT299783

Context Info Confidence 0.14 First Reported 2005 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 7 Total Number 8 Disease Relevance 6.49 Pain Relevance 2.49

plasma membrane (Cd28)

Anatomy Link Frequency T cell 2 macrophages 1 B cells 1 dendritic cells 1 Cd28 (Mus musculus) Cd80 (Mus musculus)

Pain Link Frequency Relevance Heat Arthritis 108 98.64 rheumatoid arthritis 182 98.36 cytokine 32 91.40 abatacept 242 88.52 tolerance 28 84.24 Infliximab 2 82.36 Inflammation 8 68.76 Multiple sclerosis 6 47.84 cva 4 25.12 corticosteroid 12 18.72

Disease Link Frequency Relevance Heat Arthritis 52 98.64 Apoptosis 12 98.64 Rheumatoid Arthritis 182 98.36 Immunization 34 94.04 Experimental Arthritis 58 89.04 Ankylosis 6 87.60 Disease 134 84.32 Arthropathy 8 75.72 Death 6 69.04 INFLAMMATION 8 68.76

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In addition to the CD80/86-CD28 interaction, co-stimulation of T cell responses occurs through the CD40-CD154 interaction between APCs and T cells.

CD28 Binding (interaction) of CD80 in T cell

1) Confidence 0.14 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875641 Disease Relevance 1.00 Pain Relevance 0.49

In addition to the CD80/86-CD28 interaction, co-stimulation of T cell responses occurs through the CD40-CD154 interaction between APCs and T cells.

CD28 Binding (interaction) of CD80 in T cell

2) Confidence 0.14 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875641 Disease Relevance 1.00 Pain Relevance 0.49

These observations suggest that CD28–CD80/86 interactions are important in the initiation of the arthritis.

CD28 Binding (interactions) of CD80 associated with arthritis

3) Confidence 0.08 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833980 Disease Relevance 1.35 Pain Relevance 0.44

These observations suggest that CD28–CD80/86 interactions are important in the initiation of the arthritis.

CD28 Binding (interactions) of CD80 associated with arthritis

4) Confidence 0.08 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833980 Disease Relevance 1.35 Pain Relevance 0.44

The regulatory effects of interrupting CD28 interactions with CD80/86 have been harnessed in recombinant molecules (CTLA4–immunoglobulin [Ig]) that combine the extracellular domain of human CTLA4 with a portion of the Fc domain of IgG1 [10].

CD28 Binding (interactions) of CD80

5) Confidence 0.08 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833980 Disease Relevance 0.44 Pain Relevance 0.30

CD28 is present on most T cells and it binds to both CD80 (B7-1) and CD86 (B7-2), which are present on antigen-presenting cells, including dendritic cells, B cells, and macrophages.

CD28 Binding (binds) of CD80 in dendritic cells

6) Confidence 0.08 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833980 Disease Relevance 0.45 Pain Relevance 0.11

CD28 is present on most T cells and it binds to both CD80 (B7-1) and CD86 (B7-2), which are present on antigen-presenting cells, including dendritic cells, B cells, and macrophages.

CD28 Binding (binds) of CD80 in macrophages

7) Confidence 0.03 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833980 Disease Relevance 0.45 Pain Relevance 0.11

CD28 is present on most T cells and it binds to both CD80 (B7-1) and CD86 (B7-2), which are present on antigen-presenting cells, including dendritic cells, B cells, and macrophages.

CD28 Binding (binds) of CD80 in B cells

8) Confidence 0.03 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833980 Disease Relevance 0.45 Pain Relevance 0.11

General Comments

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