INT299791

Context Info Confidence 0.18 First Reported 2005 Last Reported 2005 Negated 1 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.77 Pain Relevance 0.32

plasma membrane (CD28, CTLA4) cytosol (CD28) Golgi apparatus (CTLA4)

Anatomy Link Frequency CD86 2 CD28 (Homo sapiens) CTLA4 (Homo sapiens)

Pain Link Frequency Relevance Heat abatacept 1 95.12 psoriasis 4 91.12 rheumatoid arthritis 53 87.52 Inflammation 62 62.08 Arthritis 13 40.76 cytokine 24 36.16 tolerance 4 5.00 metalloproteinase 2 5.00 corticosteroid 1 5.00 methotrexate 1 5.00

Disease Link Frequency Relevance Heat Psoriasis 4 91.12 Rheumatoid Arthritis 53 87.52 Adhesions 4 86.24 Graft Vs Host Disease 1 84.08 Organ Transplantation 1 83.00 Immune System Diseases 2 68.00 INFLAMMATION 59 62.08 Disease 24 48.16 Autoimmune Disease 17 43.44 Arthritis 13 40.76

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Because CD152 has a high affinity for CD80 and CD86, soluble forms of CTLA4 inhibit the interaction of CD28 with its ligands.

Negative_regulation (inhibit) of CD28 Neg (inhibit) Binding (interaction) of CTLA4 in CD86

1) Confidence 0.18 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833981 Disease Relevance 0.77 Pain Relevance 0.32

General Comments

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