INT300199

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Context Info
Confidence 0.13
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.88
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lysosome (PCSK9, LDLR) transport (LDLR) small molecule metabolic process (LDLR)
lipid metabolic process (LDLR) extracellular space (PCSK9) peptidase activity (PCSK9)
Anatomy Link Frequency
plasma 2
PCSK9 (Homo sapiens)
LDLR (Homo sapiens)
Pain Link Frequency Relevance Heat
alcohol 2 10.00 Low Low
Bile 16 5.00 Very Low Very Low Very Low
cva 7 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
nud 2 5.00 Very Low Very Low Very Low
aspirin 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
pruritus 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperlipoproteinemia Type Ii 5 97.68 Very High Very High Very High
Hyperlipidemia 9 95.04 Very High Very High Very High
Disorder Of Lipid Metabolism 150 84.32 Quite High
Hypolipidemia 2 83.44 Quite High
Hypoalphalipoproteinemias 2 80.32 Quite High
Hyperlipoproteinemia Type Iv 2 40.52 Quite Low
Pancreatitis 2 39.20 Quite Low
Disease 5 32.64 Quite Low
Dyslipidemia /

Combined Dyslipidemia

15 21.84 Low Low
Diabetes Mellitus 5 11.52 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PCSK9 destroys low density lipoproteins receptors (LDL-C-R) in the liver, thereby regulating the levels of LDL-C in plasma.
PCSK9 Regulation (regulating) of Gene_expression (levels) of LDL-C-R in plasma
1) Confidence 0.13 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2835557 Disease Relevance 0.88 Pain Relevance 0

General Comments

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