INT3002

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Context Info
Confidence 0.24
First Reported 1978
Last Reported 2011
Negated 5
Speculated 2
Reported most in Body
Documents 62
Total Number 64
Disease Relevance 55.90
Pain Relevance 14.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SUGT1) mitosis (SUGT1)
Anatomy Link Frequency
blood 3
body 2
muscle 1
B18 1
skin 1
SUGT1 (Homo sapiens)
SUGT1 - R151C (1)
Pain Link Frequency Relevance Heat
Catechol-O-methyltransferase 163 100.00 Very High Very High Very High
cINOD 113 100.00 Very High Very High Very High
aspirin 60 100.00 Very High Very High Very High
spinal inflammation 136 99.76 Very High Very High Very High
melanocortin 1 receptor 17 99.70 Very High Very High Very High
Opioid 87 99.68 Very High Very High Very High
alcohol 153 99.56 Very High Very High Very High
Pain 280 99.48 Very High Very High Very High
Dopamine 34 99.32 Very High Very High Very High
Analgesic 145 98.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 923 100.00 Very High Very High Very High
Coronary Artery Disease 270 100.00 Very High Very High Very High
Hyperlipidemia 192 100.00 Very High Very High Very High
Alzheimer's Dementia 167 100.00 Very High Very High Very High
Complex Regional Pain Syndromes 10 99.94 Very High Very High Very High
Disorder Of Lipid Metabolism 105 99.84 Very High Very High Very High
Stomach Cancer 35 99.84 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 13 99.80 Very High Very High Very High
Cancer 293 99.76 Very High Very High Very High
Hypertension 130 99.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS: These findings may help to explain previous research suggesting that naltrexone is more effective among individuals with the G allele.
allele Binding (individuals) of
1) Confidence 0.24 Published 2004 Journal Alcohol. Clin. Exp. Res. Section Body Doc Link 15608594 Disease Relevance 0 Pain Relevance 0
RESULTS: The results suggested that individuals with the G allele reported higher subjective feelings of intoxication, stimulation, sedation, and happiness across trials as compared with participants with the A allele.
allele Binding (individuals) of
2) Confidence 0.24 Published 2004 Journal Alcohol. Clin. Exp. Res. Section Body Doc Link 15608594 Disease Relevance 0 Pain Relevance 0
Profound muscle fatigue is a predominant and debilitating symptom in a proportion or patients with angina and normal coronary arteriograms (ANCA), and we postulated that the gene D allele might be associated with the presence of fatigue in ANCA patients.
allele Spec (might) Binding (associated) of in muscle associated with angina and fatigue
3) Confidence 0.08 Published 2005 Journal Int. J. Cardiol. Section Abstract Doc Link 15686789 Disease Relevance 0.55 Pain Relevance 0.17
Genetic influences are recognized through the apoE4 allele, which is associated with hypercholesterolemia and is a risk factor in vascular events and Alzheimer disease, and is recognized for its proinflammatory profile.
allele Binding (recognized) of associated with alzheimer's dementia and hyperlipidemia
4) Confidence 0.07 Published 2005 Journal Neurobiol. Aging Section Abstract Doc Link 15639305 Disease Relevance 1.71 Pain Relevance 0.18
Genetic influences are recognized through the apoE4 allele, which is associated with hypercholesterolemia and is a risk factor in vascular events and Alzheimer disease, and is recognized for its proinflammatory profile.
allele Binding (associated) of associated with alzheimer's dementia and hyperlipidemia
5) Confidence 0.07 Published 2005 Journal Neurobiol. Aging Section Abstract Doc Link 15639305 Disease Relevance 1.72 Pain Relevance 0.18
Genetic influences are recognized through the apoE4 allele, which is associated with hypercholesterolemia and is a risk factor in vascular events and Alzheimer disease, and is recognized for its proinflammatory profile.
allele Binding (recognized) of associated with alzheimer's dementia and hyperlipidemia
6) Confidence 0.07 Published 2005 Journal Neurobiol. Aging Section Abstract Doc Link 15639305 Disease Relevance 1.79 Pain Relevance 0.19
Within the alcohol dependent group, the Asp40 allele was associated with more drinking days.
Asp40 allele Binding (associated) of associated with alcohol
7) Confidence 0.07 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687624 Disease Relevance 0.42 Pain Relevance 0.38
Blum et al. [10] provided the first evidence that the dopamine D2 receptor gene (DRD2) Taq 1 A1 allele significantly associated with severe alcoholism whereby the author's suggested that they found the first "reward gene" located in the mesolimbic system.
allele Binding (associated) of associated with alcohol addiction and dopamine
8) Confidence 0.06 Published 2010 Journal Med. Hypotheses Section Abstract Doc Link 19914781 Disease Relevance 0.33 Pain Relevance 0.66
A previous report of an insertion/deletion (I/D) polymorphism in intron 16 within the ACE gene implicated an increased risk to develop CRPS I associated with the D allele.
D allele Binding (associated) of associated with complex regional pain syndromes
9) Confidence 0.05 Published 2004 Journal Eur J Pain Section Abstract Doc Link 15109972 Disease Relevance 0.86 Pain Relevance 0.16
In 3 studies related to gastric cancer, Ala12 allele has been found to be associated with increased risk of gastric cancer [199–201] and this effect of PPAR?
allele Binding (associated) of associated with stomach cancer
10) Confidence 0.05 Published 2009 Journal PPAR Research Section Body Doc Link PMC2669649 Disease Relevance 1.46 Pain Relevance 0.07
In comparison, there is no evidence to show a significant association of Ala12 allele with colorectal cancer in an Indian (Asia) population [198].
allele Binding (association) of associated with colon cancer
11) Confidence 0.05 Published 2009 Journal PPAR Research Section Body Doc Link PMC2669649 Disease Relevance 1.52 Pain Relevance 0.08
Yet again, studies do show that Ala12 allele either is associated with increased risk of myocardial infarction [165, 166], or attenuates the protective effect of polyunsaturated fatty acids on myocardial infarction [167], or confers excess hazard of developing cardiovascular diseases in patients with diabetic nephropathy [168].
allele Binding (associated) of associated with cardiovascular disease, renal disease and myocardial infarction
12) Confidence 0.05 Published 2009 Journal PPAR Research Section Body Doc Link PMC2669649 Disease Relevance 1.66 Pain Relevance 0.06
A significant association of the T allele with essential hypertension or obesity has been suggested.
allele Binding (association) of associated with obesity and hypertension
13) Confidence 0.05 Published 2000 Journal Rinsho Byori Section Abstract Doc Link 10804812 Disease Relevance 0.68 Pain Relevance 0.09
The most studied thus far is the association between Ala12 allele with the risk of colorectal cancer.
allele Binding (association) of associated with colon cancer
14) Confidence 0.04 Published 2009 Journal PPAR Research Section Body Doc Link PMC2669649 Disease Relevance 1.57 Pain Relevance 0.11
Indeed, one study suggests there is an association between Ala12 allele and increased body mass [182].
allele Binding (association) of in body
15) Confidence 0.04 Published 2009 Journal PPAR Research Section Body Doc Link PMC2669649 Disease Relevance 0.59 Pain Relevance 0.04
In Mexican Americans, subjects with the Ala12 allele become more obese only when they also carry the Trp64Arg of Beta-3 adrenergic receptor (?
allele Binding (subjects) of associated with obesity
16) Confidence 0.04 Published 2009 Journal PPAR Research Section Body Doc Link PMC2669649 Disease Relevance 1.02 Pain Relevance 0.04
Interestingly, Pro12Ala mutation interacts with body size at birth to modulate cholesterol metabolism since an association between increased concentration of serum total, LDL- and non-HDL-cholesterol and Ala12 allele can be found only in those who had birth weights below 3 kilograms [158].
allele Binding (found) of in body associated with birth weight and disorder of lipid metabolism
17) Confidence 0.04 Published 2009 Journal PPAR Research Section Body Doc Link PMC2669649 Disease Relevance 1.14 Pain Relevance 0.09
However, others have suggested either a potential contribution of Ala12 variant to hypertension [115] or an association of Ala12 allele with higher diastolic blood pressure in obese patients with T2D [150] while couple of studies fails to show an association between the PPAR?
allele Binding (association) of in blood associated with diabetes mellitus, obesity and hypertension
18) Confidence 0.04 Published 2009 Journal PPAR Research Section Body Doc Link PMC2669649 Disease Relevance 1.12 Pain Relevance 0.03
In 3 studies related to gastric cancer, Ala12 allele has been found to be associated with increased risk of gastric cancer [199–201] and this effect of PPAR?
allele Binding (found) of associated with stomach cancer
19) Confidence 0.04 Published 2009 Journal PPAR Research Section Body Doc Link PMC2669649 Disease Relevance 1.45 Pain Relevance 0.07
Ala12 allele is inversely associated with blood TAG concentrations in one report [54] while it has also been found to be associated with a trend of an increase in TAG and hyperlipidemia in another [152].
allele Binding (associated) of in blood associated with hyperlipidemia
20) Confidence 0.04 Published 2009 Journal PPAR Research Section Body Doc Link PMC2669649 Disease Relevance 1.20 Pain Relevance 0.03

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