INT300376

Context Info Confidence 0.73 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.41 Pain Relevance 0

MIR1-1 (Homo sapiens)

Pain Link Frequency Relevance Heat tolerance 13 5.00 Chronic pancreatitis 2 5.00 Pain 2 5.00 Central nervous system 1 5.00 Spinal cord 1 5.00 withdrawal 1 5.00 cINOD 1 5.00 local anesthetic 1 5.00 Bile 1 5.00 lidocaine 1 5.00

Disease Link Frequency Relevance Heat Obesity 7 95.16 Cancer 169 92.96 Apoptosis 5 75.92 Insulin Resistance 35 50.00 Diabetes Mellitus 79 5.00 Disease 23 5.00 Prostate Cancer 20 5.00 Pancreatic Cancer 14 5.00 Impaired Glucose Tolerance 13 5.00 Reprotox - General 3 11 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These pri-miRNA transcripts are processed by the RNase III enzyme Drosha and its cofactor, DGCR8, to release an approximately 70-nucleotide pre-miRNA precursor product.

Localization (release) of miR

1) Confidence 0.73 Published 2010 Journal Silenc Section Body Doc Link PMC2835996 Disease Relevance 0.23 Pain Relevance 0

The Taqman® MicroRNA assay (Applied Biosystems), which detects mature miRNA, was used to measure miR-1 (Cat#4373161), miR-133a (Cat#4373142), miR-133b (Cat# 4373172) and miR-206 (Cat#4373092).

Localization (measure) of miR-1

2) Confidence 0.09 Published 2010 Journal Genome Med Section Body Doc Link PMC2847700 Disease Relevance 0.19 Pain Relevance 0

General Comments

This test has worked.