INT300486

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Context Info
Confidence 0.15
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.91
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (ROS1) cell proliferation (ROS1) extracellular space (LEP)
extracellular region (LEP) plasma membrane (ROS1) lipid metabolic process (LEP)
Anatomy Link Frequency
endothelial cells 1
LEP (Homo sapiens)
ROS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Bioavailability 1 74.08 Quite High
Inflammatory response 1 63.52 Quite High
Inflammation 8 51.36 Quite High
Inflammatory marker 1 40.44 Quite Low
Serotonin 12 29.28 Quite Low
Neurotransmitter 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 1 99.60 Very High Very High Very High
Metabolic Syndrome 28 98.50 Very High Very High Very High
Stress 6 88.96 High High
Weight Gain 3 69.12 Quite High
Heart Disease 2 66.36 Quite High
Pressure And Volume Under Development 3 65.64 Quite High
INFLAMMATION 10 63.16 Quite High
Obesity 9 56.96 Quite High
Weight Loss 7 50.00 Quite Low
Body Weight 12 27.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As human obesity is associated with hyperleptinemia and atherosclerosis, it was shown that leptin, in addition to its angiogenic properties, exerts proatherogenic effect on endothelial cells by increasing reactive oxygen species (ROS) formation.
leptin Positive_regulation (increasing) of ROS in endothelial cells associated with metabolic syndrome and increased venous pressure under development
1) Confidence 0.15 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2836327 Disease Relevance 0.91 Pain Relevance 0.09

General Comments

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