INT300489

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Context Info
Confidence 0.41
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.12
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (LEP) extracellular region (LEP) lipid metabolic process (LEP)
Anatomy Link Frequency
hypothalamus 4
LEP (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 16 81.80 Quite High
Serotonin 24 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Inflammatory marker 2 5.00 Very Low Very Low Very Low
Neurotransmitter 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 12 82.52 Quite High
INFLAMMATION 20 81.80 Quite High
Metabolic Syndrome 56 79.80 Quite High
Weight Gain 6 79.32 Quite High
Obesity 18 60.00 Quite High
Weight Loss 14 50.00 Quite Low
Diabetes Mellitus 8 39.52 Quite Low
Body Weight 24 34.72 Quite Low
Disease 6 12.48 Low Low
Overweight 4 10.48 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In vivo and in vitro research done at the University of Pittsburgh demonstrated that CRP binds to leptin thereby impairing its signaling in two ways: 1) the coupling of CRP to leptin makes crossing the blood-brain barrier nearly impossible, thus preventing "free" leptin access to the hypothalamus; 2) the CRP/leptin complex inhibits the binding of leptin to its receptors, thus blocking its ability to signal in cultured cells.
Negative_regulation (inhibits) of leptin Binding (binding) of in hypothalamus
1) Confidence 0.41 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2836327 Disease Relevance 0.56 Pain Relevance 0.08
In vivo and in vitro research done at the University of Pittsburgh demonstrated that CRP binds to leptin thereby impairing its signaling in two ways: 1) the coupling of CRP to leptin makes crossing the blood-brain barrier nearly impossible, thus preventing "free" leptin access to the hypothalamus; 2) the CRP/leptin complex inhibits the binding of leptin to its receptors, thus blocking its ability to signal in cultured cells.
Negative_regulation (inhibits) of leptin Binding (binding) of in hypothalamus
2) Confidence 0.41 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2836327 Disease Relevance 0.56 Pain Relevance 0.08

General Comments

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