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Context Info
Confidence 0.10
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.44
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

DNA binding (TBX21, Hand1) nucleus (TBX21, Hand1) cell differentiation (Hand1)
nucleoplasm (Hand1) enzyme binding (Hand1) cytoplasm (Hand1)
Anatomy Link Frequency
Th1 cells 1
TBX21 (Homo sapiens)
Hand1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 49 92.16 High High
Inflammation 25 71.04 Quite High
rheumatoid arthritis 56 68.48 Quite High
chemokine 2 58.24 Quite High
Arthritis 86 52.64 Quite High
Crohn's disease 5 5.00 Very Low Very Low Very Low
Nicotine 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
colic 1 5.00 Very Low Very Low Very Low
nud 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 20 71.04 Quite High
Rheumatoid Arthritis 57 68.48 Quite High
Arthritis 69 67.92 Quite High
Disease 49 50.04 Quite High
Hypersensitivity 17 27.84 Quite Low
Seronegative Spondarthritis 7 26.76 Quite Low
Agammaglobulinemia 4 21.44 Low Low
Experimental Arthritis 7 17.68 Low Low
Syndrome 31 5.00 Very Low Very Low Very Low
Infection 17 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, the gene encoding for T-bet, the master regulator of Th1 differentiation, was found to be in an active state, according to histone methylation marks, in both Th17 and Treg cells.
T-bet Regulation (regulator) of Th1
1) Confidence 0.10 Published 2010 Journal Semin Immunopathol Section Body Doc Link PMC2836464 Disease Relevance 0.38 Pain Relevance 0.19
Th2 cells, regulated by GATA3 and STAT6 transcription factors, enhance IgE CSR (IL-4 and IL-13) and synthesis, while Th1 cells, regulated by T-bet and STAT4, inhibit the Th2-IgE axis.
T-bet Regulation (regulated) of Th1 in Th1 cells
2) Confidence 0.02 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2837605 Disease Relevance 0.07 Pain Relevance 0.29

General Comments

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