INT300617

Context Info Confidence 0.28 First Reported 2005 Last Reported 2005 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.53 Pain Relevance 0

ATPase activity (MSH6, MLH1) nucleus (MSH6, MLH1) nuclear chromosome (MSH6) cell cycle (MLH1)

Anatomy Link Frequency MLH1 1 MSH6 (Homo sapiens) MLH1 (Homo sapiens)

Pain Link Frequency Relevance Heat COX2 3 5.00 abdominal pain 3 5.00 cINOD 1 5.00

Disease Link Frequency Relevance Heat Cancer 25 88.48 Colorectal Cancer 51 84.12 Adenoma 2 82.68 Hereditary Nonpolyposis Colorectal Neoplasms 7 12.48 Familial Adenomatous Polyposis 47 5.00 Polyps 24 5.00 Syndrome 17 5.00 Stomach Cancer 9 5.00 Endometriosis (extended) 6 5.00 Rectal Cancer 5 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Since the discovery of the major human gene with DNA misrepair function in 1993-1995, mutations in MSH2, MLH1, MSH6 and PMS2 have been convincingly associated with HNPCC.

MSH6 Binding (associated) of HNPCC in MLH1

1) Confidence 0.28 Published 2005 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2837058 Disease Relevance 0.53 Pain Relevance 0

General Comments

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