INT300748

Context Info Confidence 0.38 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.55 Pain Relevance 0

IGHE (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 16 44.00 Inflammation 10 5.00 rheumatoid arthritis 2 5.00 fibrosis 1 5.00 Nicotine 1 5.00 alcohol 1 5.00 abdominal pain 1 5.00 colic 1 5.00 chemokine 1 5.00 tolerance 1 5.00

Disease Link Frequency Relevance Heat Agammaglobulinemia 4 96.56 Hypersensitivity 17 89.40 General Immunology 7 79.44 Rheumatoid Arthritis 3 69.56 Deficiency Diseases 2 40.16 Immunodeficiency 2 37.68 Ataxia 1 32.80 Infection 16 23.44 Disease 19 14.40 Syndrome 25 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

IgE hypogammaglobulinemia is currently defined as a significant decrease in serum levels of IgE (<2.5 IU/mL) in a patient whose other immunoglobulin levels are normal (selective IgE deficiency) or diminished (mixed IgE deficiency).

Negative_regulation (diminished) of Negative_regulation (deficiency) of IgE associated with agammaglobulinemia

1) Confidence 0.38 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2837605 Disease Relevance 0.55 Pain Relevance 0

General Comments

This test has worked.