INT300856

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Context Info
Confidence 0.09
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.06
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Bdnf, Il6) extracellular space (Il6) cytoplasmic membrane-bounded vesicle (Bdnf)
Bdnf (Mus musculus)
Il6 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 8 43.88 Quite Low
Inflammation 13 43.48 Quite Low
Calcitonin gene-related peptide 1 17.20 Low Low
Inflammatory response 4 10.48 Low Low
Arthritis 3 5.00 Very Low Very Low Very Low
psoriasis 2 5.00 Very Low Very Low Very Low
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
trk B 1 5.00 Very Low Very Low Very Low
qutenza 1 5.00 Very Low Very Low Very Low
Multiple sclerosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 4 58.56 Quite High
Lung Injury 1 49.32 Quite Low
Burns 1 48.52 Quite Low
INFLAMMATION 17 43.48 Quite Low
Hematological Disease 12 39.20 Quite Low
Malignant Neoplastic Disease 2 38.64 Quite Low
Infection 3 5.84 Low Low
Apoptosis 5 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our data suggest ERK and p38 MAPK pathways are required for optimal BMSC IL-6 induction by NGF and BDNF, with these pathways likely involved in baseline expression of IL-6 as a reduction in steady state expression was noted with both inhibitors in the absence of any neurotrophic stimulation.
BDNF Positive_regulation (required) of Positive_regulation (induction) of IL-6
1) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2837737 Disease Relevance 0.06 Pain Relevance 0

General Comments

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