INT300877

Context Info Confidence 0.04 First Reported 2010 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.16 Pain Relevance 0

cell differentiation (AKT1) nucleoplasm (AKT1) transport (AKT1) extracellular space (Il6) protein modification process (AKT1) nucleus (AKT1)

AKT1 (Homo sapiens) Il6 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 13 5.00 cytokine 8 5.00 Inflammatory response 4 5.00 Arthritis 3 5.00 psoriasis 2 5.00 rheumatoid arthritis 2 5.00 trk B 1 5.00 qutenza 1 5.00 Multiple sclerosis 1 5.00 Calcitonin gene-related peptide 1 5.00

Disease Link Frequency Relevance Heat Hematological Disease 12 82.08 INFLAMMATION 17 5.00 Apoptosis 5 5.00 Targeted Disruption 4 5.00 Disease 3 5.00 Infection 3 5.00 Arthritis 2 5.00 Neurodegenerative Disease 2 5.00 Asthma 2 5.00 Systemic Lupus Erythematosus 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Akt inhibition did not decrease IL-6 protein detected in BMSC supernatants (data not shown).

Negative_regulation (inhibition) of Akt Neg (not) Negative_regulation (decrease) of IL-6 protein

1) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2837737 Disease Relevance 0.16 Pain Relevance 0

General Comments

This test has worked.