INT301246

Context Info Confidence 0.03 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.74 Pain Relevance 0

nucleus (HMGB1, Hbp1) DNA binding (HMGB1, Hbp1) nucleoplasm (HMGB1) extracellular space (HMGB1) extracellular region (HMGB1) nucleolus (HMGB1)

HMGB1 (Homo sapiens) Hbp1 (Mus musculus)

Pain Link Frequency Relevance Heat anesthesia 1 5.00 isoflurane 1 5.00

Disease Link Frequency Relevance Heat Leukemia 17 95.88 Breast Cancer 2 93.76 Targeted Disruption 2 78.48 Myeloid Leukemia 56 75.76 Myelodysplastic Syndromes 1 71.32 Myeloproliferative Disorder 22 70.12 Hematologic Neoplasms 2 68.28 Disease 8 57.88 Malignant Neoplastic Disease 3 37.28 Lifespan 1 32.76

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

HBP1 is a high mobility group protein that interacts with and is transcriptionally regulated by Rb, functionally inhibits G1 to G2/S phase cell cycling in leukemia cell lines, and is associated with invasive breast cancer (Tevosian et al., 1997; Shih et al., 1998; Yao et al., 2005; Paulson et al., 2007).

high mobility group protein Binding (interacts) of HBP1 associated with leukemia and breast cancer

1) Confidence 0.03 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839143 Disease Relevance 0.74 Pain Relevance 0

General Comments

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