INT301261

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Context Info
Confidence 0.58
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.68
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Clec5a)
Anatomy Link Frequency
joint 1
Clec5a (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 72 98.80 Very High Very High Very High
tetrodotoxin 11 96.88 Very High Very High Very High
sodium channel 2 89.12 High High
Action potential 2 84.24 Quite High
Arthritis 74 70.00 Quite High
cytokine 14 50.48 Quite High
Pain 4 44.52 Quite Low
rheumatoid arthritis 16 32.08 Quite Low
imagery 9 15.44 Low Low
agonist 40 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 60 98.80 Very High Very High Very High
Hypercalcemia 14 98.80 Very High Very High Very High
Arthritis 106 95.92 Very High Very High Very High
Osteoporosis 4 93.68 High High
Injury 4 91.96 High High
Fever 3 79.16 Quite High
Congenital Anomalies 2 72.80 Quite High
Arthropathy 10 70.72 Quite High
Disease 44 65.20 Quite High
Hemorrhagic Diathesis 2 48.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Functional blockade of MDL-1 receptor via Mdl1 deletion or treatment with MDL-1-Ig fusion protein reduces the clinical signs of autoimmune joint inflammation.
Negative_regulation (blockade) of MDL-1 receptor in joint associated with inflammation and arthritis
1) Confidence 0.58 Published 2010 Journal The Journal of Experimental Medicine Section Abstract Doc Link PMC2839155 Disease Relevance 0.59 Pain Relevance 0.21
In this study, we show that blocking MDL-1–DAP12 predominantly reduced tissue inflammation by reducing TNF, IL-1?
Negative_regulation (blocking) of MDL-1-DAP12 associated with inflammation
2) Confidence 0.43 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839155 Disease Relevance 1.01 Pain Relevance 0.26
M (final concentration) of the adenylyl cyclase inhibitor MDL (Sigma).
Negative_regulation (inhibitor) of MDL
3) Confidence 0.41 Published 2010 Journal Mol Syst Biol Section Body Doc Link PMC3010105 Disease Relevance 0.08 Pain Relevance 0.18

General Comments

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