INT301272

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Context Info
Confidence 0.69
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 13
Disease Relevance 6.17
Pain Relevance 2.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Clec5a)
Anatomy Link Frequency
osteoclasts 4
inflammatory macrophages 2
neutrophils 2
joint 1
myeloid cell 1
Clec5a (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 468 99.92 Very High Very High Very High
agonist 260 98.48 Very High Very High Very High
cytokine 91 98.08 Very High Very High Very High
Arthritis 481 93.80 High High
antagonist 52 62.48 Quite High
Inflammatory response 26 55.40 Quite High
Pain 26 14.08 Low Low
rheumatoid arthritis 104 10.28 Low Low
imagery 39 5.00 Very Low Very Low Very Low
fibrosis 13 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthritis 689 99.92 Very High Very High Very High
INFLAMMATION 390 98.64 Very High Very High Very High
Disease 286 98.20 Very High Very High Very High
Injury 26 97.76 Very High Very High Very High
Hypercalcemia 91 95.32 Very High Very High Very High
Pressure And Volume Under Development 117 95.08 Very High Very High Very High
Arthropathy 65 94.72 High High
Congenital Anomalies 13 78.60 Quite High
Bone Cancer 26 72.24 Quite High
Leukoencephalopathies 13 52.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also demonstrate that MDL-1 activation increases the expression of NFATc1 and ATPV0D2, which control cell fusion (Lee et al., 2006), as well as regulating bone resorption via TRAP and cathepsin K in osteoclasts (Takayanagi, 2005a).
Positive_regulation (activation) of MDL-1 in osteoclasts associated with hypercalcemia
1) Confidence 0.69 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839155 Disease Relevance 0.94 Pain Relevance 0.28
Activation of MDL-1 leads to enhanced recruitment of inflammatory macrophages and neutrophils to the joint and promotes bone erosion.
Positive_regulation (Activation) of MDL-1 in inflammatory macrophages associated with inflammation
2) Confidence 0.69 Published 2010 Journal The Journal of Experimental Medicine Section Abstract Doc Link PMC2839155 Disease Relevance 0.52 Pain Relevance 0.17
Interestingly, even through MDL-1 activation enhanced TNF, IL-6, RANK, and TRAP expression, both type I and II IFNs were undetectable in the inflamed paws (the Q-PCR cycle threshold is ?
Positive_regulation (activation) of MDL-1
3) Confidence 0.50 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839155 Disease Relevance 0.37 Pain Relevance 0.29
By testing serum samples during the course of disease, we found that the osteoclast-specific TRAP 5b levels were significantly increased after MDL-1 receptor activation (Fig. 4 C).
Positive_regulation (activation) of MDL-1 receptor in osteoclast associated with disease
4) Confidence 0.50 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839155 Disease Relevance 0.34 Pain Relevance 0.17
In contrast, MDL-1–Ig fusion–treated mice have bone integrity, density, volume, and bone mass values that are nearly comparable to healthy naive mice, confirming that blocking MDL-1 receptor activation maintains joint integrity.
Positive_regulation (activation) of MDL-1 receptor in joint
5) Confidence 0.50 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839155 Disease Relevance 0.21 Pain Relevance 0.20
Activation of the MDL-1 receptor during joint inflammation enhances myeloid cell infiltration and promotes IL-1, IL-6, IL-17A, and TNF expression, resulting in severe cartilage damage and bone erosion.
Positive_regulation (Activation) of MDL-1 receptor in myeloid cell associated with inflammation and arthritis
6) Confidence 0.46 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839155 Disease Relevance 0.56 Pain Relevance 0.28
It appears that MDL-1 activation contributes to two distinct cellular mechanisms of tissue destruction.
Positive_regulation (activation) of MDL-1
7) Confidence 0.46 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839155 Disease Relevance 0.65 Pain Relevance 0.27
MDL-1 activation increases the kinetics of cell fusion, resulting in greater size and frequency of mature osteoclasts (Fig. 5 B).
Positive_regulation (activation) of MDL-1 in osteoclasts
8) Confidence 0.46 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839155 Disease Relevance 0.16 Pain Relevance 0.17
Not only does MDL-1 activation recruit substantial numbers of bone marrow–derived inflammatory macrophages and neutrophils, it also promotes osteoclast activation.
Positive_regulation (activation) of MDL-1 in neutrophils associated with inflammation
9) Confidence 0.46 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839155 Disease Relevance 0.68 Pain Relevance 0.26
To investigate the immune responses regulated by MDL-1 activation, we assessed the expression of proinflammatory cytokines, osteoclast markers, and myeloid cell markers in arthritic paws.
Spec (investigate) Positive_regulation (activation) of MDL-1 in osteoclast associated with arthritis and cytokine
10) Confidence 0.46 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839155 Disease Relevance 0.40 Pain Relevance 0.25
These results suggest MDL-1 activation promotes in vitro osteoclastogenesis and cell fusion.
Positive_regulation (activation) of MDL-1
11) Confidence 0.46 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839155 Disease Relevance 0.15 Pain Relevance 0.13
Activation of MDL-1 leads to enhanced recruitment of inflammatory macrophages and neutrophils to the joint and promotes bone erosion.
Positive_regulation (Activation) of MDL-1 in neutrophils associated with inflammation
12) Confidence 0.24 Published 2010 Journal The Journal of Experimental Medicine Section Abstract Doc Link PMC2839155 Disease Relevance 0.52 Pain Relevance 0.17
Not only does MDL-1 activation recruit substantial numbers of bone marrow–derived inflammatory macrophages and neutrophils, it also promotes osteoclast activation.
Positive_regulation (activation) of MDL-1 in inflammatory macrophages associated with inflammation
13) Confidence 0.16 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839155 Disease Relevance 0.68 Pain Relevance 0.26

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