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Context Info
Confidence 0.37
First Reported 1983
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.96
Pain Relevance 2.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (TPP1) mitochondrion (TPP1) cell death (TPP1)
lipid metabolic process (TPP1) lysosome (TPP1)
Anatomy Link Frequency
neuronal 1
juvenile 1
TPP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 17 100.00 Very High Very High Very High
Opioid 1 99.52 Very High Very High Very High
Analgesic 4 99.24 Very High Very High Very High
Enkephalin 3 98.36 Very High Very High Very High
Morphine 1 97.88 Very High Very High Very High
opiate 1 81.36 Quite High
agonist 1 73.32 Quite High
analgesia 1 69.44 Quite High
potassium channel 1 36.48 Quite Low
Neuropeptide 1 32.08 Quite Low
Disease Link Frequency Relevance Heat
Ceroid Lipofuscinosis 3 98.68 Very High Very High Very High
Apoptosis 5 98.22 Very High Very High Very High
Death 2 97.84 Very High Very High Very High
Pressure Volume 2 Under Development 1 90.92 High High
Hypertension 3 81.08 Quite High
Hypotension 3 71.12 Quite High
Alzheimer's Dementia 1 27.84 Quite Low
Neurodegenerative Disease 2 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Four other subjects experienced a decrease of PS under CLN and no rebound the next night.
Negative_regulation (decrease) of CLN in CLN associated with clonidine
1) Confidence 0.37 Published 1983 Journal Sleep Section Abstract Doc Link 6302810 Disease Relevance 0 Pain Relevance 0.54
Accelerated apoptosis accounts for neurodegeneration in the late infantile and juvenile forms that are due to defects in the CLN3 and CLN2 genes.
Negative_regulation (defects) of CLN2 in juvenile associated with apoptosis
2) Confidence 0.29 Published 2002 Journal Ann. Neurol. Section Abstract Doc Link 11921051 Disease Relevance 0.42 Pain Relevance 0
Plasma renin activity (PRA) tended to increase with NIF, decreased with CLN (P < 0.05) and was unchanged with NIF + CLN.
Negative_regulation (decreased) of CLN in CLN associated with clonidine
3) Confidence 0.12 Published 1985 Journal J Hypertens Suppl Section Abstract Doc Link 2856710 Disease Relevance 0.32 Pain Relevance 0.98
A lysosomal pepstatin-insensitive proteinase (CLN2p) deficiency is the underlying defect in the classical late-infantile neuronal ceroid lipofuscinosis (LINCL, CLN2).
Negative_regulation (defect) of pepstatin-insensitive proteinase in neuronal associated with ceroid lipofuscinosis
4) Confidence 0.07 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10617131 Disease Relevance 0.17 Pain Relevance 0
The new inhibitors were compared with known renin inhibitors (RIP, pepstatin, H-77) and opioid analgesic agents (Met-enkephalin, morphine), with the following results: The new inhibitors were active against human renin (IC50 approximately 10-5M), but inactive against rat renin and pepsin.
Negative_regulation (inhibitors) of pepstatin associated with analgesic, enkephalin, opioid and morphine
5) Confidence 0.01 Published 1985 Journal Clin Exp Hypertens A Section Abstract Doc Link 3000656 Disease Relevance 0.05 Pain Relevance 0.67

General Comments

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