INT301549

Context Info Confidence 0.55 First Reported 2009 Last Reported 2009 Negated 0 Speculated 1 Reported most in Body Documents 1 Total Number 7 Disease Relevance 3.27 Pain Relevance 0.48

oxidoreductase activity (Cyp4a10) endoplasmic reticulum (Cyp4a10)

Anatomy Link Frequency hepatocytes 1 fat 1 Cyp4a10 (Mus musculus)

Pain Link Frequency Relevance Heat agonist 77 89.68 Inflammation 112 73.80 chemokine 28 58.64 cytokine 14 48.28 Kinase C 21 16.72 fibrosis 77 5.00 alcohol 35 5.00 Bile 35 5.00 methotrexate 7 5.00 fluoxetine 7 5.00

Disease Link Frequency Relevance Heat Stress 84 98.04 Repression 14 97.72 Hyperoxia 7 96.40 Nash(non-alcoholic Steatohepatitis) 189 90.20 Fatty Liver 441 90.04 Liver Disease 126 86.16 Metabolic Syndrome 161 80.64 Iron Overload 7 79.04 Autoimmune Hepatitis 7 78.36 Cholangitis 7 77.48

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The differential regulation of the CYP4A and CYP4F genes by peroxisome proliferators, during fasting and by high fat diets indicates that these P450s may have distinct roles in lipid metabolism during the fasting and feeding cycles, and that different nuclear transcription factors regulate the expression of these genes (Figure 1).

Regulation (regulation) of CYP4A in fat

1) Confidence 0.55 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.95 Pain Relevance 0.10

The modest 2-fold induction of the CYP4A11 gene by peroxisome proliferators in primary human hepatocytes compared with the 30–70 fold induction of the mouse CYP4A genes indicates a species difference between rodents and humans with respect to regulation of the CYP4A genes by peroxisome proliferators [150].

Regulation (regulation) of CYP4A in hepatocytes

2) Confidence 0.55 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.70 Pain Relevance 0.08

To resolve this issue and to further define the role of CYP4A genes in production of ROS during hepatic steatosis, mouse models overexpressing CYP4A10 and CYP4A14 will be needed to determine if excessive fatty acid induces uncoupling of the P450 catalytic cycle and generation of ROS during the progression of NAFLD to NASH.

Regulation (role) of CYP4A associated with fatty liver and nash(non-alcoholic steatohepatitis)

3) Confidence 0.40 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.36 Pain Relevance 0.13

In contrast to the extensive data on the role of rodent CYP4A gene in animal models of steatosis and steatohepatitis, little is known about how the human CYP4A11 gene is controlled by PPAR?

Regulation (rodent) of CYP4A

4) Confidence 0.40 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.54 Pain Relevance 0.09

In contrast to the extensive data on the role of rodent CYP4A gene in animal models of steatosis and steatohepatitis, little is known about how the human CYP4A11 gene is controlled by PPAR?

Regulation (role) of CYP4A

5) Confidence 0.40 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.54 Pain Relevance 0.09

This scenario is highly likely in the regulation of CYP4A and CYP4F genes since peroxisome proliferators (PP) activate PPAR?

Spec (likely) Regulation (regulation) of CYP4A

6) Confidence 0.24 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.09 Pain Relevance 0

For instance, the differential regulation of the CYP4A and CYP4F genes may be determined by cross-talk between PPAR?

Regulation (regulation) of CYP4A

7) Confidence 0.24 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.10 Pain Relevance 0

General Comments

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