INT301600

Context Info Confidence 0.47 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.28 Pain Relevance 0.13

small molecule metabolic process (CYP4F2) endoplasmic reticulum (CYP4F2)

Anatomy Link Frequency liver 1 CYP4F2 (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 2 70.40 chemokine 4 69.28 Inflammation 16 23.96 fibrosis 11 5.00 agonist 11 5.00 alcohol 5 5.00 Bile 5 5.00 Kinase C 3 5.00 methotrexate 1 5.00 fluoxetine 1 5.00

Disease Link Frequency Relevance Heat Liver Disease 18 99.40 Obesity 11 90.04 Fatty Liver 63 86.88 Celiac Disease 2 38.56 Disease 13 26.40 INFLAMMATION 15 23.96 Injury 8 18.60 Biliary Liver Cirrhosis 2 16.00 Cholangitis 1 12.16 Autoimmune Hepatitis 1 11.12

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Therefore, the activation of the CYP4F2 gene in fatty liver diseases may decrease the formation of oleic acid and storage of TAG in the liver, and also play a vital role in preventing recruitment of immune cells to the liver during steatohepatitis by metabolism of the proinflammatory leukotrienes.

Positive_regulation (activation) of CYP4F2 in liver associated with liver disease

1) Confidence 0.47 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.28 Pain Relevance 0.13

General Comments

This test has worked.