INT301615

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Context Info
Confidence 0.02
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.42
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Samsn1) mitochondrion (Cyp2e1) oxidoreductase activity (Cyp2e1)
endoplasmic reticulum (Cyp2e1) nucleus (Samsn1) enzyme binding (Cyp2e1)
Anatomy Link Frequency
liver 2
Cyp2e1 (Mus musculus)
Samsn1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 32 97.52 Very High Very High Very High
alcohol 10 82.32 Quite High
fibrosis 22 5.00 Very Low Very Low Very Low
agonist 22 5.00 Very Low Very Low Very Low
Bile 10 5.00 Very Low Very Low Very Low
chemokine 8 5.00 Very Low Very Low Very Low
Kinase C 6 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
methotrexate 2 5.00 Very Low Very Low Very Low
fluoxetine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fatty Liver 126 100.00 Very High Very High Very High
Nash(non-alcoholic Steatohepatitis) 54 100.00 Very High Very High Very High
INFLAMMATION 30 97.52 Very High Very High Very High
Disease 26 97.00 Very High Very High Very High
Ketosis 2 96.20 Very High Very High Very High
Diabetes Mellitus 34 95.88 Very High Very High Very High
Obesity 22 88.28 High High
Liver Disease 36 87.48 High High
Injury 16 80.56 Quite High
Hepatotoxicity 2 19.60 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, even with this apparently close association of CYP2E1 with both NAFLD and NASH and in several animal models of both alcoholic and nonalcoholic steatosis, Cyp2e1-null mice still develop diet-induced NASH or alcoholic liver inflammatory disease indicating that Cyp2e1 deletion neither prevented nor decreased oxidative damage [103–105].
Cyp2e1 Binding (association) of NASH in liver associated with fatty liver, nash(non-alcoholic steatohepatitis), inflammation and disease
1) Confidence 0.02 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 1.21 Pain Relevance 0.09
However, even with this apparently close association of CYP2E1 with both NAFLD and NASH and in several animal models of both alcoholic and nonalcoholic steatosis, Cyp2e1-null mice still develop diet-induced NASH or alcoholic liver inflammatory disease indicating that Cyp2e1 deletion neither prevented nor decreased oxidative damage [103–105].
CYP2E1 Binding (association) of NASH in liver associated with fatty liver, nash(non-alcoholic steatohepatitis), inflammation and disease
2) Confidence 0.02 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 1.20 Pain Relevance 0.09

General Comments

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