INT301665

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Context Info
Confidence 0.26
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.79
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ppara) small molecule metabolic process (CYP2C9) oxidoreductase activity (CYP2C9)
endoplasmic reticulum (CYP2C9) nucleus (Ppara) DNA binding (Ppara)
Anatomy Link Frequency
liver 2
CYP2C9 (Homo sapiens)
Ppara (Mus musculus)
Pain Link Frequency Relevance Heat
fluoxetine 1 100.00 Very High Very High Very High
agonist 11 99.84 Very High Very High Very High
fibrosis 11 95.20 Very High Very High Very High
Inflammation 16 5.00 Very Low Very Low Very Low
alcohol 5 5.00 Very Low Very Low Very Low
Bile 5 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
Kinase C 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
methotrexate 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 5 99.92 Very High Very High Very High
Adverse Drug Reaction 3 98.84 Very High Very High Very High
Fibrosis 8 95.20 Very High Very High Very High
Nash(non-alcoholic Steatohepatitis) 27 94.56 High High
Fatty Liver 63 94.24 High High
Diabetes Mellitus 17 84.32 Quite High
Disease Progression 3 81.88 Quite High
Hyperglycemia 3 81.12 Quite High
Cirrhosis 8 78.00 Quite High
Hepatitis 1 65.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CYP2C9 is the second most abundant P450 expressed in human liver and is responsible for the metabolism of S-warfarin, Tamoxifen, fluoxetine, losartan, and the antidiabetic PPAR?
CYP2C9 Regulation (responsible) of PPAR Binding (metabolism) of in liver associated with fluoxetine
1) Confidence 0.26 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 1.79 Pain Relevance 0.34

General Comments

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