INT302313

Context Info Confidence 0.67 First Reported 2010 Last Reported 2011 Negated 0 Speculated 0 Reported most in Body Documents 6 Total Number 6 Disease Relevance 2.06 Pain Relevance 0.08

extracellular space (SOST) extracellular region (SOST) transcription factor binding (SOST)

Anatomy Link Frequency skeleton 1 osteocyte 1 parathyroid 1 SOST (Homo sapiens)

Pain Link Frequency Relevance Heat antagonist 3 99.36 transdermal 22 34.88 fibrosis 110 31.76 carpal tunnel syndrome 4 14.88 Sciatica 4 8.00 spinal stenosis 4 6.64 cva 11 5.00 tolerance 6 5.00 Inflammation 5 5.00 Pain 4 5.00

Disease Link Frequency Relevance Heat Targeted Disruption 10 99.78 Osteoporosis 148 98.74 Disease 12 98.32 Hypercalcemia 55 98.04 Apoptosis 3 89.08 Postmenopausal Osteoporosis 17 85.64 Hematoma 3 53.96 Pressure And Volume Under Development 6 53.40 Dysphagia 3 41.20 Fracture Healing 24 40.76

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

A deletion downstream of the SOST gene, which results in reduced sclerostin expression, is associated with a milder form of the disease called van Buchem disease [5].

Gene_expression (expression) of sclerostin associated with disease

1) Confidence 0.67 Published 2010 Journal Curr Osteoporos Rep Section Body Doc Link PMC2841260 Disease Relevance 0.20 Pain Relevance 0

Several studies have reported that sclerostin gene expression and protein levels are reduced in animals treated with daily injections of human parathyroid hormone (hPTH) (1–34) [9].

Gene_expression (expression) of sclerostin gene in parathyroid

2) Confidence 0.67 Published 2010 Journal Curr Osteoporos Rep Section Body Doc Link PMC2841260 Disease Relevance 0.05 Pain Relevance 0

The molecular mechanisms underlying these anabolic effects are still poorly understood, but appear to include both direct actions on osteoblastic cells as well as indirect effects such as through stimulation of IGF-1 production and downregulation of sclerostin, a physiologic antagonist of the important anabolic Wnt-?

Gene_expression (production) of sclerostin associated with antagonist and osteoporosis

3) Confidence 0.65 Published 2010 Journal Osteoporos Int Section Body Doc Link PMC2931762 Disease Relevance 0.61 Pain Relevance 0.05

Also, studies find the increases in bone formation induced by antisclerostin antibody, unlike PTH, not associated with increases in bone resorption in the aged rodent skeleton.

Gene_expression (antibody) of sclerostin in skeleton associated with hypercalcemia

4) Confidence 0.65 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2957275 Disease Relevance 0.56 Pain Relevance 0

PTH increases bone formation through several actions, including increasing commitment of mesenchymal stem cells to the osteoblast lineage, increasing osteoblast maturation and possibly life span, and reducing the osteocyte production of sclerostin to further stimulate bone formation.

Gene_expression (production) of sclerostin in osteocyte associated with osteoporosis

5) Confidence 0.58 Published 2010 Journal Curr Osteoporos Rep Section Body Doc Link PMC2841260 Disease Relevance 0.44 Pain Relevance 0

Transgenic mice that overexpress sclerostin are seen to have low bone mass and increased susceptibility to fractures [99] while mice deficient in sclerostin show increased bone density [100].

Gene_expression (overexpress) of sclerostin associated with targeted disruption

6) Confidence 0.12 Published 2011 Journal Journal of Osteoporosis Section Body Doc Link PMC3010683 Disease Relevance 0.20 Pain Relevance 0.03

General Comments

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