INT302315

Context Info Confidence 0.61 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.11 Pain Relevance 0

extracellular space (SOST) extracellular region (SOST) transcription factor binding (SOST)

Anatomy Link Frequency osteocytes 1 kidney 1 SOST (Homo sapiens)

Pain Link Frequency Relevance Heat transdermal 14 5.00 spinal stenosis 2 5.00 carpal tunnel syndrome 2 5.00 Sciatica 2 5.00

Disease Link Frequency Relevance Heat Disease 4 58.24 Osteoporosis 32 5.00 Hypercalcemia 12 5.00 Fracture Healing 12 5.00 Pressure And Volume Under Development 4 5.00 Targeted Disruption 4 5.00 Carpal Tunnel Syndrome 4 5.00 Vomiting 4 5.00 Pressure Volume 2 Under Development 4 5.00 Postmenopausal Osteoporosis 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Sclerostin, a glycoprotein secreted by osteocytes and to a lesser extent other cell types (vascular, kidney), is a potent inhibitor of osteoblastogenesis.

Localization (secreted) of Sclerostin in kidney

1) Confidence 0.61 Published 2010 Journal Curr Osteoporos Rep Section Body Doc Link PMC2841260 Disease Relevance 0 Pain Relevance 0

Sclerostin is secreted from osteocytes and travels through the canaliculi to the bone surface where it binds to coreceptors LRP5 and LRP6 and prevents colocalization with frizzled protein and Wnt signaling, thereby reducing osteoblastogenesis and bone formation [3].

Localization (secreted) of Sclerostin in osteocytes

2) Confidence 0.53 Published 2010 Journal Curr Osteoporos Rep Section Body Doc Link PMC2841260 Disease Relevance 0.11 Pain Relevance 0

General Comments

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