INT302321

Context Info Confidence 0.16 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.26 Pain Relevance 0

extracellular space (SOST) extracellular region (SOST) endoplasmic reticulum (Lrp6) plasma membrane (Lrp6) transcription factor binding (SOST)

Lrp6 (Mus musculus) SOST (Homo sapiens)

Pain Link Frequency Relevance Heat transdermal 14 5.00 spinal stenosis 2 5.00 carpal tunnel syndrome 2 5.00 Sciatica 2 5.00

Disease Link Frequency Relevance Heat Disease 4 66.52 Hypercalcemia 12 28.56 Osteoporosis 32 21.20 Targeted Disruption 4 12.64 Fracture Healing 12 5.00 Pressure And Volume Under Development 4 5.00 Carpal Tunnel Syndrome 4 5.00 Vomiting 4 5.00 Pressure Volume 2 Under Development 4 5.00 Postmenopausal Osteoporosis 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Sclerostin (SOST) is thought to function as a paracrine inhibitor of canonical Wnt signaling on the preosteoblast surface by binding to the Wnt coreceptors LRP5 and LRP6 and blocking their colocalization with the frizzled receptor [8].

Negative_regulation (inhibitor) of LRP6 Binding (binding) of SOST

1) Confidence 0.16 Published 2010 Journal Curr Osteoporos Rep Section Body Doc Link PMC2841260 Disease Relevance 0.13 Pain Relevance 0

Sclerostin (SOST) is thought to function as a paracrine inhibitor of canonical Wnt signaling on the preosteoblast surface by binding to the Wnt coreceptors LRP5 and LRP6 and blocking their colocalization with the frizzled receptor [8].

Negative_regulation (inhibitor) of LRP6 Binding (binding) of Sclerostin

2) Confidence 0.16 Published 2010 Journal Curr Osteoporos Rep Section Body Doc Link PMC2841260 Disease Relevance 0.13 Pain Relevance 0

General Comments

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