INT302467

Context Info Confidence 0.00 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.10 Pain Relevance 0.29

extracellular region (TIMP1, COL5A2) aging (TIMP1) molecular_function (COL5A2)

TIMP1 (Homo sapiens) COL5A2 (Homo sapiens)

Pain Link Frequency Relevance Heat metalloproteinase 12 100.00 Inflammation 20 47.28 cva 14 8.40 cytokine 11 5.00 withdrawal 4 5.00 Dismenorea 4 5.00 depression 2 5.00 Inflammatory response 2 5.00 antagonist 2 5.00 iatrogenic 1 5.00

Disease Link Frequency Relevance Heat Rupture 16 100.00 Mixed Connective Tissue Disorder 1 95.96 Lacerations 1 93.28 Infection 50 89.20 Premature Birth 141 80.36 Pre-term Labor 20 70.96 INFLAMMATION 23 47.28 Pathologic Processes 2 12.32 Hemorrhage 14 8.40 Stress 21 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Loss of collagen and structural strength leading to rupture of the membranes is mediated by matrix metalloproteinases (MMPs), a large family of enzymes that act to degrade collagen and remodel tissue.

metalloproteinases Positive_regulation (mediated) of Negative_regulation (Loss) of collagen associated with rupture and metalloproteinase

1) Confidence 0.00 Published 2010 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC2841774 Disease Relevance 1.10 Pain Relevance 0.29

General Comments

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