INT302611

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Context Info
Confidence 0.43
First Reported 2010
Last Reported 2010
Negated 7
Speculated 0
Reported most in Body
Documents 1
Total Number 11
Disease Relevance 4.50
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Rac1) enzyme binding (Rac1) GTPase activity (Rac1)
cytoplasm (Rac1) cell proliferation (Rac1) cell motility (Rac1)
Anatomy Link Frequency
endothelial cells 8
vascular endothelium 2
Rac1 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 22 52.40 Quite High
cINOD 11 5.00 Very Low Very Low Very Low
antagonist 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 935 99.96 Very High Very High Very High
Targeted Disruption 66 99.46 Very High Very High Very High
Skin Cancer 22 83.20 Quite High
Pathologic Neovascularization 33 69.48 Quite High
Cv Unclassified Under Development 44 52.40 Quite High
Increased Venous Pressure Under Development 22 51.12 Quite High
Stress 22 42.72 Quite Low
Colorectal Cancer 44 5.00 Very Low Very Low Very Low
Metastasis 33 5.00 Very Low Very Low Very Low
Adhesions 22 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As expected, no significant changes in either mRNA or protein levels of Rac1 or Flk-1 were observed in pSico-Con infected cells (Figure 2B).
Neg (no) Regulation (changes) of Gene_expression (levels) of Rac1
1) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0.47 Pain Relevance 0
Importantly, tamoxifen treatment of non-endothelial cells isolated from Rac1 flox/flox PDGFB-iCreER mice had no effect on Rac1 expression (Figure 4A).
Neg (no) Regulation (effect) of Gene_expression (expression) of Rac1 in endothelial cells
2) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0.37 Pain Relevance 0
3-null mice were all dependent on endothelial Rac1 expression since Rac1-depletion in ?
Regulation (dependent) of Gene_expression (expression) of Rac1
3) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0.81 Pain Relevance 0
However, pSico-Rac1 treatment had no effect in wild-type/Tie1-Cre+ mice, but did inhibit neovascularization in ?
Neg (no) Regulation (effect) of Gene_expression (treatment) of pSico-Rac1
4) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0.19 Pain Relevance 0
3-integrin knockout endothelial cells without affecting total Rac1 levels, and that transduction of human ?
Neg (without) Regulation (affecting) of Gene_expression (levels) of Rac1 in endothelial cells associated with targeted disruption
5) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0.77 Pain Relevance 0
3-null mice were all dependent on endothelial Rac1 expression since Rac1-depletion in ?
Regulation (dependent) of Gene_expression (expression) of Rac1-depletion
6) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0.81 Pain Relevance 0
In contrast, transfection of endothelial cells using Con siRNA had no effect on Rac1 expression in either genotype.
Neg (no) Regulation (effect) of Gene_expression (expression) of Rac1 in endothelial cells
7) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0 Pain Relevance 0
Deletion of Rac1 in the vascular endothelium did not affect tumor size or tumor angiogenesis when compared with controls (Figure 4B).
Neg (not) Regulation (affect) of Gene_expression (Deletion) of Rac1 in vascular endothelium associated with cancer
8) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0.37 Pain Relevance 0
To begin to understand the mechanisms responsible for the biological effects of Rac1-depletion in wild-type and ?
Regulation (responsible) of Gene_expression (effects) of Rac1-depletion
9) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0 Pain Relevance 0
Taken together these data suggest that Rac1 expression in endothelial cells is not essential for VEGF-mediated angiogenesis in wild-type mice but is involved in such responses in ?
Neg (not) Regulation (essential) of Gene_expression (expression) of Rac1 in endothelial cells
10) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0 Pain Relevance 0
3-null, but not wild-type mice, are dependent on adult endothelial Rac1 expression
Regulation (dependent) of Gene_expression (expression) of Rac1
11) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0.70 Pain Relevance 0.03

General Comments

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