INT302775

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Context Info
Confidence 0.27
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.84
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

kinase activity (Syk) cytoplasm (Syk)
Syk (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 64 99.72 Very High Very High Very High
chemokine 2 95.52 Very High Very High Very High
cytokine 15 94.92 High High
Inflammation 43 89.16 High High
rheumatoid arthritis 65 57.20 Quite High
Central nervous system 1 45.88 Quite Low
methotrexate 4 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Osteoarthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthritis 62 99.72 Very High Very High Very High
Synovitis 1 98.04 Very High Very High Very High
INFLAMMATION 17 81.88 Quite High
Autoimmune Disease 2 63.56 Quite High
Rheumatoid Arthritis 65 57.20 Quite High
Nervous System Inflammation 1 46.40 Quite Low
Diarrhoea 1 39.60 Quite Low
Neutropenia 2 38.48 Quite Low
Apoptosis 45 5.00 Very Low Very Low Very Low
Cancer 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The reduced expression of SyK in the R788-treated mice correlated with an amelioration of clinical arthritis, a reduction in proinflammatory chemokines and cytokines, including the CXCR2 ligand KC-GRO-?
Negative_regulation (reduced) of Gene_expression (expression) of SyK associated with chemokine, cytokine and arthritis
1) Confidence 0.27 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 0.84 Pain Relevance 0.48

General Comments

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