INT302831

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Context Info
Confidence 0.07
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.30
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Creb1, Mapkapk5) mitochondrion (Creb1) DNA binding (Creb1)
kinase activity (Mapkapk5) transcription factor binding (Creb1) response to stress (Mapkapk5)
Creb1 (Mus musculus)
Mapkapk5 (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 128 98.76 Very High Very High Very High
Inflammation 86 98.36 Very High Very High Very High
methotrexate 8 89.28 High High
rheumatoid arthritis 130 86.84 High High
Inflammatory response 6 80.80 Quite High
cytokine 30 69.32 Quite High
agonist 4 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Osteoarthritis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthritis 124 98.76 Very High Very High Very High
Rheumatoid Arthritis 130 86.84 High High
Apoptosis 90 83.00 Quite High
INFLAMMATION 34 80.40 Quite High
Shock 2 75.28 Quite High
Cancer 24 56.80 Quite High
Pressure And Volume Under Development 2 6.64 Low Low
Necrosis 10 5.00 Very Low Very Low Very Low
Death 6 5.00 Very Low Very Low Very Low
Juvenile Chronic Polyarthritis 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the MK5/PRAK promoters of human, mouse and rat all contain a cyclic AMP (cAMP) responsive element that binds to CREB in vitro [96], indicating that molecules involved in inflammatory arthritis that also activate cAMP-dependent protein kinase A (e.g., PGE2), may also upregulate MK5/PRAK transcription.
CREB Binding (binds) of MK5 associated with inflammation and arthritis
1) Confidence 0.07 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 0.65 Pain Relevance 0.40
However, the MK5/PRAK promoters of human, mouse and rat all contain a cyclic AMP (cAMP) responsive element that binds to CREB in vitro [96], indicating that molecules involved in inflammatory arthritis that also activate cAMP-dependent protein kinase A (e.g., PGE2), may also upregulate MK5/PRAK transcription.
CREB Binding (binds) of PRAK associated with inflammation and arthritis
2) Confidence 0.07 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 0.65 Pain Relevance 0.40

General Comments

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