INT302834

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Context Info
Confidence 0.05
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.02
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il7) extracellular region (Il7) cell adhesion (Cd4)
plasma membrane (Cd4) enzyme binding (Cd4)
Anatomy Link Frequency
T-cell 2
Cd4 (Mus musculus)
Il7 (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 64 98.32 Very High Very High Very High
rheumatoid arthritis 65 94.88 High High
cytokine 15 71.04 Quite High
Inflammation 43 70.68 Quite High
methotrexate 4 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Osteoarthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthritis 62 98.32 Very High Very High Very High
Rheumatoid Arthritis 65 94.88 High High
Targeted Disruption 1 83.80 Quite High
Arthropathy 1 79.80 Quite High
Apoptosis 45 47.48 Quite Low
INFLAMMATION 17 5.00 Very Low Very Low Very Low
Cancer 12 5.00 Very Low Very Low Very Low
Necrosis 5 5.00 Very Low Very Low Very Low
Death 3 5.00 Very Low Very Low Very Low
Juvenile Chronic Polyarthritis 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, arthritis produced in these mice by the F759 mutation in gp130 required not only homeostatic CD4+ T-cell expansion but upregulation of IL-7 gene expression in nonhemopoietic cells as well.
CD4 Positive_regulation (upregulation) of Gene_expression (expression) of IL-7 in T-cell associated with arthritis
1) Confidence 0.05 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 1.02 Pain Relevance 0.54

General Comments

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