INT302940

Context Info Confidence 0.37 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 1.53 Pain Relevance 0.10

signal transduction (Smpd3) Golgi apparatus (Smpd3) cell cycle (Smpd3) response to stress (Smpd3)

Anatomy Link Frequency fibroblasts 1 Smpd3 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 8 84.76 agonist 12 65.84 cytokine 6 5.00 metalloproteinase 2 5.00 anesthesia 2 5.00 Inflammatory response 2 5.00

Disease Link Frequency Relevance Heat Stress 38 99.60 Apoptosis 126 99.24 INFLAMMATION 10 84.76 Necrosis 6 75.36 Osteogenic Sarcomas 4 66.36 Toxicity 16 34.12 Leukemia 2 24.96 Death 10 5.00 Osteogenesis Imperfecta 8 5.00 Alzheimer's Dementia 4 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

was apparently independent of nSMase2 and SM hydrolysis in murine fibroblasts, since similar apoptosis was observed in nSMase2-deficient cells, and since rescuing the activity of the nSMase2 did not alter the apoptosis induced by TNF?

nSMase2 Binding (activity) of in fibroblasts associated with apoptosis

1) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2843740 Disease Relevance 1.02 Pain Relevance 0.04

In order to define the specific contributions of nSMase2 to these stress responses, the activation of the SM/Cer pathway by TNF?

nSMase2 Binding (contributions) of associated with stress

2) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2843740 Disease Relevance 0.51 Pain Relevance 0.06

General Comments

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