INT303195

Context Info Confidence 0.42 First Reported 2010 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.08 Pain Relevance 0.06

cell differentiation (Shank1) plasma membrane (Shank1) intracellular (Shank1) protein complex assembly (Shank1) cytoplasm (Shank1)

Anatomy Link Frequency neurons 2 Shank1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat tetrodotoxin 4 62.48 Glutamate receptor 2 5.00 imagery 1 5.00

Disease Link Frequency Relevance Heat Attention Deficit Hyperactivity Disorder 1 83.52 Syndrome 2 5.00 Anxiety Disorder 1 5.00 Intellectual Impairment 1 5.00 Cognitive Disorder 1 5.00 Disease 1 5.00 Autism 1 5.00 Angelman Syndrome 1 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In neurons expressing TRIM3/264 shRNA, bicuculline treatment failed to lower GKAP protein expression, despite a higher “baseline” level of GKAP (Figure 4D, E).

Neg (failed) Positive_regulation (lower) of Gene_expression (expression) of GKAP protein in neurons

1) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844417 Disease Relevance 0.08 Pain Relevance 0.06

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