INT303209

Context Info Confidence 0.34 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0

cell differentiation (Shank1) plasma membrane (Shank1) intracellular (Shank1) protein complex assembly (Shank1) cytoplasm (Shank1)

Anatomy Link Frequency neurons 2 Shank1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat tetrodotoxin 4 5.00 Glutamate receptor 2 5.00 imagery 1 5.00

Disease Link Frequency Relevance Heat Syndrome 2 5.00 Anxiety Disorder 1 5.00 Attention Deficit Hyperactivity Disorder 1 5.00 Intellectual Impairment 1 5.00 Cognitive Disorder 1 5.00 Disease 1 5.00 Autism 1 5.00 Angelman Syndrome 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The fact that TRIM3 knockdown shows some selectivity in its effect on postsynaptic scaffold proteins, and that it increases postsynaptic accumulation of GFP-Shank1A, would argue against a non-specific toxic effect of TRIM3 RNAi in neurons.

Positive_regulation (increases) of Positive_regulation (accumulation) of GFP-Shank1A in neurons

1) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844417 Disease Relevance 0 Pain Relevance 0

General Comments

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