INT303394

Context Info Confidence 0.04 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.38 Pain Relevance 0

cytoplasm (Myh3, Mul1) signal transduction (Mul1) mitochondrion (Mul1) peroxisome (Mul1) nucleus (Mul1) ligase activity (Mul1)

Myh3 (Mus musculus) Mul1 (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 1 19.12 imagery 2 5.00 Spinal cord 1 5.00 Pain 1 5.00 Sciatic nerve 1 5.00

Disease Link Frequency Relevance Heat Frailty 4 95.00 Hypertrophy 1 91.48 Muscular Atrophy 9 59.36 Injury 1 14.24 Pain 1 5.00 Sprains And Strains 1 5.00 Targeted Disruption 1 5.00 Nutritional Deficiencies 1 5.00 Stress 1 5.00 Appetite Loss 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Here we present evidence that the Ozz-E3 ligase, by binding to the rod domain of a fully assembled MyHCemb, marks it for ubiquitination and degradation, probably facilitating the subsequent assembly of new isoforms.

MyHCemb Binding (binding) of E3 ligase

1) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844429 Disease Relevance 0.38 Pain Relevance 0

General Comments

This test has worked.