INT303889

Context Info Confidence 0.05 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.23 Pain Relevance 0

unfolded protein binding (Serpinh1) endoplasmic reticulum (Serpinh1) protein maturation (Serpinh1) response to stress (Serpinh1) cytoplasm (Serpinh1)

Anatomy Link Frequency ventricles 1 Serpinh1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat metalloproteinase 4 21.52 Action potential 29 5.00 fibrosis 2 5.00 action potential duration 2 5.00 Nav1.1 1 5.00

Disease Link Frequency Relevance Heat Hypertrophy 6 84.24 Aging 11 73.12 Obesity 3 72.00 Heart Rate Under Development 9 5.00 Fibrosis 5 5.00 Targeted Disruption 1 5.00 Body Weight 1 5.00 Necrosis 1 5.00 Disease 1 5.00 Cancer 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

It is possible that, in the ventricles, the decrease in MMP mRNA is the dominating influence and, consequently, there is an age-dependent increase in collagen protein, whereas, in the SAN, the decreases of collagen and MMP mRNAs are more balanced and there can be no age-dependent change in collagen protein [8] or even a decrease as in the present study.

Regulation (change) of collagen protein in ventricles

1) Confidence 0.05 Published 2010 Journal Journal of Molecular and Cellular Cardiology Section Body Doc Link PMC2845824 Disease Relevance 0.23 Pain Relevance 0

General Comments

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