INT304188

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Context Info
Confidence 0.06
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.60
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (VEGFA) signal transducer activity (Agtr2) signal transduction (Agtr2)
extracellular space (VEGFA) growth (VEGFA) extracellular region (VEGFA)
Anatomy Link Frequency
fibroblasts 2
Agtr2 (Mus musculus)
VEGFA (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 14 96.88 Very High Very High Very High
anesthesia 2 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatic Cancer 42 96.56 Very High Very High Very High
Cancer 168 87.12 High High
Disease 4 70.40 Quite High
Adenocarcinoma 22 64.32 Quite High
Apoptosis 30 39.56 Quite Low
Death 6 5.00 Very Low Very Low Very Low
Pancreatic Ductal Carcinoma 6 5.00 Very Low Very Low Very Low
Malignant Neoplastic Disease 6 5.00 Very Low Very Low Very Low
Sprains And Strains 2 5.00 Very Low Very Low Very Low
Hypertension 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although these studies did not clarify the potential second messenger that controls cell growth, the present study suggests that AT2 receptor-mediated attenuation of VEGF production is a potential mechanism for AT2 receptor expression-dependent growth attenuation of pancreatic carcinoma.
AT2 receptor-mediated Negative_regulation (attenuation) of Gene_expression (production) of VEGF associated with pancreatic cancer
1) Confidence 0.06 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2846883 Disease Relevance 0.51 Pain Relevance 0
Angiotensin II attenuated VEGF production in fibroblasts, and this attenuation was blocked by an AT2 receptor specific antagonist
Angiotensin II Negative_regulation (attenuated) of Gene_expression (production) of VEGF in fibroblasts associated with antagonist
2) Confidence 0.06 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2846883 Disease Relevance 0.09 Pain Relevance 0.12

General Comments

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