INT305018

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Context Info
Confidence 0.68
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 39
Disease Relevance 23.31
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (NREP) cytoplasm (NREP)
Anatomy Link Frequency
fibroblast 17
margin 3
smooth muscle 2
internal 2
bone marrow 1
NREP (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 21 99.14 Very High Very High Very High
cytokine 39 93.20 High High
Osteoarthritis 7 83.48 Quite High
Inflammation 46 77.84 Quite High
pruritus 32 68.08 Quite High
Pain 39 67.28 Quite High
dysesthesia 32 66.48 Quite High
fibrosis 21 39.12 Quite Low
Disease Link Frequency Relevance Heat
Dermal Scarring 336 100.00 Very High Very High Very High
Injury 245 100.00 Very High Very High Very High
Keloid Scars 1802 99.84 Very High Very High Very High
Cicatrix 448 99.56 Very High Very High Very High
Burns 128 97.24 Very High Very High Very High
Cytomegalovirus Infection 96 84.40 Quite High
Disease 207 83.92 Quite High
Osteoarthritis 7 83.48 Quite High
INFLAMMATION 46 77.84 Quite High
Wound Healing 117 76.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of C5ORF13 has been shown to induce nonfibrogenic myofibroblast-like phenotype in 3T3 cells, including upregulation of smooth muscle ?
Gene_expression (expression) of C5ORF13 in smooth muscle
1) Confidence 0.68 Published 2010 Journal Eplasty Section Body Doc Link PMC2851107 Disease Relevance 0.70 Pain Relevance 0.13
As the activities of P311 in human fibroblast function are unknown, we examined the distribution of it and the effects of forced expression or silencing of expression of P311.
Gene_expression (expression) of P311 in fibroblast
2) Confidence 0.65 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2852399 Disease Relevance 0.54 Pain Relevance 0
The expression pattern of P311 mRNA was examined in several human cell types by means of RT-PCR.
Spec (examined) Gene_expression (expression) of P311 mRNA
3) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852399 Disease Relevance 0.15 Pain Relevance 0
R2.30 The authors have also suggested that C5ORF13 reduces the expression of matrix metalloproteinase (MMP)-2 and MMP-9 mRNA.30 It has been postulated that the expression of C5ORF13 is found in human wound myofibroblast precursors and myofibroblasts; C5ORF13-induced myofibroblasts are thought to migrate in an ameboid pattern on fibrin structures found in the initial wound matrix, and the ameboid pattern is reversed to mesenchymal pattern upon stimulation with TGF-?
Gene_expression (expression) of C5ORF13 associated with injury and metalloproteinase
4) Confidence 0.59 Published 2010 Journal Eplasty Section Body Doc Link PMC2851107 Disease Relevance 0.63 Pain Relevance 0.18
1.30 The expression of C5ORF13 is shown to be upregulated by approximately 10-fold in keloid margin (P = .000).
Gene_expression (expression) of C5ORF13 in margin associated with dermal scarring
5) Confidence 0.59 Published 2010 Journal Eplasty Section Body Doc Link PMC2851107 Disease Relevance 0.69 Pain Relevance 0.07
P311 expression was detected in fibroblast-like cells from the hypertrophic scar of burn injury patients but not in peripheral blood mononuclear cells, bone marrow mesenchymal stem cells, epidermal cells or normal skin dermal cells.
Gene_expression (expression) of P311 in mononuclear cells associated with burns, injury and keloid scars
6) Confidence 0.57 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2852399 Disease Relevance 0.55 Pain Relevance 0
Moreover, in their study the expression of P311 was associated with downregulation of TGF-?
Gene_expression (expression) of P311
7) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852399 Disease Relevance 0.68 Pain Relevance 0.07
Moreover, the proportion of cells in S phase was increased from 0.3% to 6.0% following P311 expression (Fig. 2C and 2D).
Gene_expression (expression) of P311
8) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852399 Disease Relevance 0.32 Pain Relevance 0
P311 was readily detectable in dermal fibroblast-like cells derived from hypertrophic scar tissue.
Gene_expression (detectable) of P311 in fibroblast associated with keloid scars
9) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852399 Disease Relevance 0.17 Pain Relevance 0
In contrast, interference of fibroblast P311 gene expression decreased the TGF-?
Gene_expression (expression) of P311 in fibroblast
10) Confidence 0.57 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2852399 Disease Relevance 0.54 Pain Relevance 0
A statistically significant (P < .05) differential expression and a fold change of more than 2 were determined between keloid margin and internal control biopsy samples for 10 genes, including ACAN, ASPN, C5orf13, HIF1A, IGFBP7, INHBA, LGALS1, PTN, SERPINH1, and TNFAIP6 (Table 5).
Gene_expression (expression) of C5orf13 in internal associated with dermal scarring
11) Confidence 0.52 Published 2010 Journal Eplasty Section Body Doc Link PMC2851107 Disease Relevance 0.23 Pain Relevance 0
Ten of these 19 genes, including ACAN, ASPN, C5orf13, HIF1A, IGFBP7, INHBA, LGALS1, PTN, SERPINH1, and TNFAIP6 (Table 5), demonstrated a statistically significant difference for the gene expression levels between keloid margin and internal control skin.
Gene_expression (expression) of C5orf13 in internal associated with dermal scarring
12) Confidence 0.52 Published 2010 Journal Eplasty Section Body Doc Link PMC2851107 Disease Relevance 0.67 Pain Relevance 0
An examination of P311 mRNA expression in a number of human cell types revealed that P311 mRNA expression was only detected in hypertrophic scar-derived fibroblast-like cells.
Gene_expression (expression) of P311 mRNA in fibroblast associated with keloid scars
13) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852399 Disease Relevance 0.79 Pain Relevance 0
Conversely inhibition of P311 gene expression resulted in a reduction in the expression of TGF-?
Gene_expression (expression) of P311
14) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852399 Disease Relevance 0.29 Pain Relevance 0
An examination of P311 mRNA expression in a number of human cell types revealed that P311 mRNA expression was only detected in hypertrophic scar-derived fibroblast-like cells.
Gene_expression (expression) of P311 mRNA in fibroblast associated with keloid scars
15) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852399 Disease Relevance 0.77 Pain Relevance 0
Expression of P311 gene was associated with an enhanced level of contraction in normal and hypertrophic scar-derived fibroblasts (Fig. 3).
Gene_expression (Expression) of P311 in fibroblasts associated with keloid scars
16) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852399 Disease Relevance 0.48 Pain Relevance 0
Therefore, in the present study, we examined the effects of forced and silenced P311 gene expression on human fibroblasts functions in vitro.


Gene_expression (expression) of P311 in fibroblasts
17) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852399 Disease Relevance 1.28 Pain Relevance 0.21
Preparation of replication defective adenovirus expression vector containing human P311 gene (P311)
Gene_expression (expression) of P311
18) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852399 Disease Relevance 0.21 Pain Relevance 0
Following transduction with a P311 expression vector, ?
Gene_expression (expression) of P311
19) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852399 Disease Relevance 0.31 Pain Relevance 0
Meanwhile, Pan et. al. showed that P311 was found in human wounds during healing and disappeared after wound healed [7].
Gene_expression (disappeared) of P311 associated with injury
20) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852399 Disease Relevance 1.27 Pain Relevance 0

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