INT305137

Context Info Confidence 0.12 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 4 Disease Relevance 0.52 Pain Relevance 0

Anatomy Mention Frequency gamete 1 p47 (Mamestra configurata NPV-B)

Pain Term Frequency Confidence Heat Pain 4 33.00

Disease Term Frequency Confidence Heat Targeted Disruption 24 99.74 Malaria 24 97.52 Infection 24 79.72 Bites And Stings 8 74.72 Pain 4 33.00 Sprains And Strains 4 5.00 Salivary Gland Disease 4 5.00 Adhesions 8 5.00 Contagious Ecthyma 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Our studies demonstrate that P. berghei females lacking P47 are not recognized by wild type males.

Negative_regulation (lacking) of P47

1) Confidence 0.12 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2851734 Disease Relevance 0 Pain Relevance 0

In order to determine which residues of p230, p47 and p48/45 genes were under positive selection in the rodent malaria parasites, a Bayes Empirical Bayes (BEB) analysis was performed using sequences from the 3 rodent genomes and was calculated as described in Yang et al. [49].

Negative_regulation (residues) of p47 associated with malaria

2) Confidence 0.12 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2851734 Disease Relevance 0.10 Pain Relevance 0

p47 indicate that the few fertilisation events in single knock-out mutants deficient in expression of either P47 or P48/P45 (this study and [4]) cannot be explained by a compensation effect due to its paralogous protein because the ?

Negative_regulation (deficient) of P47 associated with targeted disruption

3) Confidence 0.12 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2851734 Disease Relevance 0.42 Pain Relevance 0

Although we found that gametes lacking expression of these proteins did not show a significant reduction in fertilisation, the effect of their absence on gamete fertility may only become evident in the absence of P48/45, P47 and P230.

Negative_regulation (absence) of P47 in gamete

4) Confidence 0.12 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2851734 Disease Relevance 0 Pain Relevance 0

General Comments

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