INT305148

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Context Info
Confidence 0.52
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.57
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (SPEN) RNA binding (SPEN) nucleus (SPEN)
DNA binding (SPEN)
SPEN (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 3 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 2 95.64 Very High Very High Very High
Hepatitis B Virus Infection 3 95.20 Very High Very High Very High
Hepatitis 3 94.68 High High
Hepatocellular Cancer 42 72.48 Quite High
Disease Progression 3 43.04 Quite Low
Bacterial Meningitis 2 26.60 Quite Low
Diarrhoea 14 5.00 Very Low Very Low Very Low
Fatigue 12 5.00 Very Low Very Low Very Low
Syndrome 12 5.00 Very Low Very Low Very Low
Toxicity 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
None of the data/signals were of sufficient quality to allow heavy-atom finding de novo, but using the partial model BUSTER-TNT phases in SHARP allowed the detection of six Pt sites and one Hg site, and also confirmed (with peaks higher than 3?
Gene_expression (phases) of SHARP
1) Confidence 0.52 Published 2010 Journal Acta Crystallographica Section D: Biological Crystallography Section Body Doc Link PMC2852306 Disease Relevance 0 Pain Relevance 0
The flexibility of the SHARP (Vonrhein et al., 2007 ?)
Gene_expression (flexibility) of SHARP
2) Confidence 0.52 Published 2010 Journal Acta Crystallographica Section D: Biological Crystallography Section Body Doc Link PMC2852306 Disease Relevance 0 Pain Relevance 0
Despite a shorter median survival in patients on placebo indicating a worse population than the SHARP study, a prespecified subgroup analysis showed a clinical benefit in all subgroups including patients with worse ECOG PS, vascular invasion, age ?
Gene_expression (study) of SHARP
3) Confidence 0.04 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886319 Disease Relevance 0.57 Pain Relevance 0

General Comments

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