INT305511

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Context Info
Confidence 0.03
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.10
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc17a6) mitochondrion (Sod1) aging (Sod1)
peroxisome (Sod1) intracellular (Sod1) protein complex (Sod1)
Anatomy Link Frequency
motor neurons 2
Sod1 (Mus musculus)
Slc17a6 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 36 78.32 Quite High
Neurotransmitter 3 74.12 Quite High
Spinal cord 7 73.20 Quite High
GABAergic 2 55.80 Quite High
Thalamus 7 48.08 Quite Low
Pain 6 19.96 Low Low
Hippocampus 8 5.00 Very Low Very Low Very Low
Central nervous system 5 5.00 Very Low Very Low Very Low
Neuropathic pain 5 5.00 Very Low Very Low Very Low
Eae 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Motor Neuron Diseases 14 98.80 Very High Very High Very High
Paralysis 1 89.00 High High
Disease 10 86.80 High High
Death 1 80.72 Quite High
Weight Loss 1 64.40 Quite High
Epilepsy 7 39.80 Quite Low
Convulsion 3 37.56 Quite Low
Pain 6 19.96 Low Low
Targeted Disruption 30 5.00 Very Low Very Low Very Low
Schizophrenia 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To test this hypothesis, we crossed our Vglut2flox/+mice with a Sod1G93A mouse, a well characterized model for ALS which has previously been demonstrated to show an ALS-like phenotype with progressive loss of motor neurons.
Negative_regulation (crossed) of Sod1G93A Binding (+mice) of Vglut2flox in motor neurons associated with motor neuron diseases
1) Confidence 0.03 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853350 Disease Relevance 1.10 Pain Relevance 0.20

General Comments

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