INT3057

From wiki-pain
Revision as of 02:55, 23 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.58
First Reported 1977
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 60
Total Number 60
Disease Relevance 14.54
Pain Relevance 11.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ptgfr) plasma membrane (Ptgfr) signal transducer activity (Ptgfr)
Anatomy Link Frequency
plasma 3
myometrium 2
epithelial cells 2
uterine 2
PGE2 2
Ptgfr (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 985 100.00 Very High Very High Very High
agonist 59 100.00 Very High Very High Very High
orphanin 4 100.00 Very High Very High Very High
Neuropeptide 1 100.00 Very High Very High Very High
allodynia 9 99.96 Very High Very High Very High
Dismenorea 59 99.86 Very High Very High Very High
Serotonin 12 99.52 Very High Very High Very High
Inflammation 73 99.04 Very High Very High Very High
cINOD 14 98.64 Very High Very High Very High
lidocaine 20 98.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 145 99.98 Very High Very High Very High
Neuropathic Pain 9 99.96 Very High Very High Very High
Reprotox - General 1 174 99.86 Very High Very High Very High
Endometriosis (extended) 218 99.84 Very High Very High Very High
Diuresis 1 99.76 Very High Very High Very High
Dysmenorrhea 14 99.68 Very High Very High Very High
Fetal Death 2 99.58 Very High Very High Very High
Adenocarcinoma 153 99.36 Very High Very High Very High
Missed Abortion 1 99.32 Very High Very High Very High
Natriuresis 1 99.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We previously showed that prostaglandin (PG) E(2), PGF(2alpha) or the neuropeptide nociceptin, also called orphanin FQ (N/OFQ) administered intrathecally (i.t.) produced allodynia in conscious mice.
Gene_expression (produced) of PGF associated with allodynia, orphanin and neuropeptide
1) Confidence 0.58 Published 2006 Journal Eur. J. Neurosci. Section Abstract Doc Link 16519664 Disease Relevance 1.26 Pain Relevance 1.34
Thus, cervical ripening induced by PGE2 does not depend on uterine contractions, and increased production of PGF2 alpha is unrelated to the ripening process.
Gene_expression (production) of PGF2 in PGE2 associated with dismenorea
2) Confidence 0.45 Published 1985 Journal Obstet Gynecol Section Abstract Doc Link 2857479 Disease Relevance 0.25 Pain Relevance 0.16
CONCLUSIONS: Ketorolac completely blocks ritodrine-stimulated production of PGF2 alpha in pregnant uterine tissues.
Gene_expression (production) of PGF2 in uterine
3) Confidence 0.45 Published 1993 Journal Obstet Gynecol Section Body Doc Link 8437778 Disease Relevance 0 Pain Relevance 0
The gene expression trends of GAS5 [125], GNB2L1 [126], MT-ND3, NKX3-1 [127], PCGEM1 [128], PTGFR [129], STEAP1 [130], and TMEM30A [131] were in agreement with the presence of proliferating cells in CRPC.
Gene_expression (expression) of PTGFR in ND3 associated with reprotox - general 1
4) Confidence 0.41 Published 2010 Journal BMC Med Genomics Section Body Doc Link PMC2956710 Disease Relevance 0.58 Pain Relevance 0.17
It is selectively more potent against the production of PGF2 alpha and PGE2 than against the formation of 6-keto PGF1 alpha, the stable metabolite of prostacyclin.
Gene_expression (production) of PGF2
5) Confidence 0.35 Published 1985 Journal Prostaglandins Leukot Med Section Abstract Doc Link 3927320 Disease Relevance 0.13 Pain Relevance 0.33
PGE2 is the main prostanoid but synovial cells are also capable of producing 6-keto-PGF1 alpha and PGF2 alpha.
Gene_expression (producing) of PGF2 in synovial cells
6) Confidence 0.34 Published 1987 Journal Clin. Rheumatol. Section Abstract Doc Link 3113811 Disease Relevance 0.43 Pain Relevance 0.39
Hydrocortisone was needed for higher concentrations to inhibit PGE2, 6-keto-PGF1 alpha and PGF2 alpha production.
Gene_expression (production) of PGF2
7) Confidence 0.34 Published 1987 Journal Clin. Rheumatol. Section Abstract Doc Link 3113811 Disease Relevance 0.36 Pain Relevance 0.41
The FP receptor is highly expressed in the distal convoluted tubule, where it may have a distinct effect on renal salt transport.
Gene_expression (expressed) of FP receptor in distal convoluted tubule
8) Confidence 0.18 Published 2001 Journal Annu. Rev. Physiol. Section Abstract Doc Link 11181968 Disease Relevance 0.36 Pain Relevance 0.03
Probably, the specific therapeutical effect of Mg based on inhibition of biosynthesis of PGF2 alpha but also on its direct muscle relaxant and vasodilatory effect.
Gene_expression (biosynthesis) of PGF2 in muscle
9) Confidence 0.10 Published 1989 Journal Zentralbl Gynakol Section Abstract Doc Link 2675496 Disease Relevance 0.15 Pain Relevance 0.24
In order to investigate prostanoid integrative signaling, we stably transfected the EP2 receptor into Ishikawa cells stably expressing the FP receptor.
Gene_expression (expressing) of FP receptor
10) Confidence 0.09 Published 2010 Journal Cell Signal Section Body Doc Link PMC2791881 Disease Relevance 0.13 Pain Relevance 0
EP2 and FP receptor expression in stably transfected Ishikawa cells
Gene_expression (expression) of FP receptor
11) Confidence 0.09 Published 2010 Journal Cell Signal Section Body Doc Link PMC2791881 Disease Relevance 0 Pain Relevance 0
The site of EP2 and FP receptor expression in FPS32 and FPEP2 cells were localised using immunofluorescence microscopy as described previously [19].
Gene_expression (expression) of FP receptor
12) Confidence 0.09 Published 2010 Journal Cell Signal Section Body Doc Link PMC2791881 Disease Relevance 0 Pain Relevance 0.05
Western blot analysis (Fig. 1C) and immunofluorescence microscopy (Fig. 1D) confirmed elevated expression of EP2 receptor protein in the FPEP2 cells compared to the FPS32 cells while the FP receptor expression was not altered between the two cell lines.
Gene_expression (expression) of FP receptor
13) Confidence 0.09 Published 2010 Journal Cell Signal Section Body Doc Link PMC2791881 Disease Relevance 0 Pain Relevance 0
There was no significant difference in expression of EP1, EP3, EP4 and the FP receptor between the FPEP2 cell line and the parental FPS32 cell line (Fig. 1B).
Gene_expression (expression) of FP receptor
14) Confidence 0.09 Published 2010 Journal Cell Signal Section Body Doc Link PMC2791881 Disease Relevance 0 Pain Relevance 0
In order to investigate the cross-talk between the EP2 and FP receptors, we created a stable cell line expressing the EP2 and FP receptor in Ishikawa cells (FPEP2 cells).
Gene_expression (expressing) of FP receptor
15) Confidence 0.09 Published 2010 Journal Cell Signal Section Body Doc Link PMC2791881 Disease Relevance 0 Pain Relevance 0
Introduction of the EP2 receptor had no effect on the expression profile of the other E-series receptors and of FP receptor which could be activated by prostanoid ligands in our study.
Gene_expression (expression) of FP receptor
16) Confidence 0.08 Published 2010 Journal Cell Signal Section Body Doc Link PMC2791881 Disease Relevance 0.07 Pain Relevance 0.03
The EP2 and FP receptor primary antibodies were purchased from Cayman Chemical Company (Axxora, Nottingham, UK) and primary antibody for actin was purchased from Santa Cruz Biotechnology (Santa Cruz, Wiltshire, UK).
Gene_expression (purchased) of FP receptor
17) Confidence 0.08 Published 2010 Journal Cell Signal Section Body Doc Link PMC2791881 Disease Relevance 0 Pain Relevance 0.17
PGF potentiates Butaprost-stimulated cAMP production via FP receptor-G?
Gene_expression (production) of FP receptor
18) Confidence 0.08 Published 2010 Journal Cell Signal Section Body Doc Link PMC2791881 Disease Relevance 0 Pain Relevance 0
The FP receptor is a G?
Gene_expression (The) of FP receptor
19) Confidence 0.08 Published 2010 Journal Cell Signal Section Body Doc Link PMC2791881 Disease Relevance 0 Pain Relevance 0
These results suggest that ritodrine stimulates PGF2 alpha production, and this may contribute to the tachyphylaxis that occurs with ritodrine and limits its long-term effectiveness as a tocolytic agent.
Gene_expression (production) of PGF2
20) Confidence 0.08 Published 1991 Journal Obstet Gynecol Section Abstract Doc Link 1923191 Disease Relevance 0 Pain Relevance 0.06

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox