INT305733

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.12
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Kcnk2) RNA binding (Gtf3a) nucleus (Gtf3a)
intracellular (Gtf3a) DNA binding (Gtf3a)
Anatomy Link Frequency
plasma 2
Gtf3a (Mus musculus)
Kcnk2 (Mus musculus)
Pain Link Frequency Relevance Heat
potassium channel 6 73.44 Quite High
depression 34 66.20 Quite High
antidepressant 66 64.40 Quite High
Raphe 4 28.92 Quite Low
Nucleus accumbens 2 28.36 Quite Low
Hippocampus 9 27.60 Quite Low
amygdala 2 27.08 Quite Low
fluoxetine 16 5.00 Very Low Very Low Very Low
sSRI 9 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 34 66.20 Quite High
Stress 7 58.44 Quite High
Injury 2 37.44 Quite Low
Death 2 16.44 Low Low
Neurodegenerative Disease 16 5.00 Very Low Very Low Very Low
Anxiety Disorder 13 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low
Shock 3 5.00 Very Low Very Low Very Low
Body Weight 2 5.00 Very Low Very Low Very Low
Decapitation 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of TREK-1 within the plasma membranes, measured either by preparing purified plasma membranes or by using cell surface biotinylation, was enhanced (by a factor 3 and 6, respectively) when COS-7 cells were cotransfected with NTSR3/Sortilin (Figure 1C), confirming the interaction between the two proteins, at least during the channel sorting.
factor Positive_regulation (enhanced) of Gene_expression (expression) of TREK-1 in plasma
1) Confidence 0.01 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2854129 Disease Relevance 0.12 Pain Relevance 0.10

General Comments

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