INT305975

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Context Info
Confidence 0.60
First Reported 2010
Last Reported 2011
Negated 1
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 3.19
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (SELS) plasma membrane (SELS) enzyme binding (SELS)
cytoplasm (SELS)
Anatomy Link Frequency
adipose tissue 2
adipocytes 2
SELS (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 23 94.56 High High
cytokine 16 93.52 High High
Inflammatory marker 6 24.72 Low Low
Angina 8 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
COX2 1 5.00 Very Low Very Low Very Low
member 8 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Neurotransmitter 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 16 98.64 Very High Very High Very High
Obesity 143 98.00 Very High Very High Very High
INFLAMMATION 28 94.56 High High
Chronic Disease 3 84.96 Quite High
Diabetes Mellitus 46 84.48 Quite High
Cardiovascular Disease 11 80.96 Quite High
Disorder Of Lipid Metabolism 24 80.32 Quite High
Insulin Resistance 15 77.68 Quite High
Apoptosis 12 72.84 Quite High
Metabolic Disorder 8 36.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SelS expression is positively regulated by NF-?
Regulation (regulated) of Gene_expression (expression) of SelS
1) Confidence 0.60 Published 2010 Journal Biol Trace Elem Res Section Body Doc Link PMC2855032 Disease Relevance 0.94 Pain Relevance 0.17
To further investigate the link between glycemic control and SELS gene expression, we analyzed the effect of insulin stimulation on isolated subcutaneous adipocytes and found that the expression of SELS increased after insulin stimulation (Fig. 1, P = .008).
Spec (investigate) Regulation (control) of Gene_expression (expression) of SELS in adipocytes associated with obesity
2) Confidence 0.45 Published 2011 Journal Metabolism Section Body Doc Link PMC3004038 Disease Relevance 0.87 Pain Relevance 0
In obese subjects, the levels of SAA in adipose tissue are higher than those in lean subjects, a fact that could possibly have effects on the ligand-receptor signaling even without large effects on SELS expression.
Neg (without) Regulation (effects) of Gene_expression (expression) of SELS in adipose tissue associated with obesity
3) Confidence 0.24 Published 2011 Journal Metabolism Section Body Doc Link PMC3004038 Disease Relevance 1.38 Pain Relevance 0.04

General Comments

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