INT306339

Context Info Confidence 0.53 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.27 Pain Relevance 0

nucleus (CRX, PAX6) cell differentiation (PAX6) nucleolus (PAX6) DNA binding (PAX6) transcription factor binding (PAX6) cytoplasm (PAX6)

Anatomy Link Frequency photoreceptor 1 CRX (Homo sapiens) PAX6 (Homo sapiens)

Pain Link Frequency Relevance Heat Central nervous system 1 5.00 anesthesia 1 5.00

Disease Link Frequency Relevance Heat Rod Or Cone Dystrophy 1 75.04 Congenital Anomalies 7 74.80 Aniridia 4 54.96 Aphasia 1 24.60 Cataract 4 22.68 Corneal Opacity 8 22.00 Ocular Toxicity (including Many Sub-types) 7 5.00 Microphthalmia 3 5.00 Ocular Hypertension 3 5.00 Disease 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

To our knowledge, PAX6 protein can bind to the CRX promoter region in a selective manner [17], which supports its role as a direct transcriptional repressor of photoreceptor fate.

CRX Binding (bind) of PAX6 in photoreceptor

1) Confidence 0.53 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2855731 Disease Relevance 0.27 Pain Relevance 0

General Comments

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