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Context Info
Confidence 0.05
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.16
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TP63) nucleoplasm (TP63) anatomical structure formation involved in morphogenesis (TP63)
Golgi apparatus (TP63) nucleolus (TP63) nucleus (TP63)
Anatomy Link Frequency
skin 2
TP63 (Homo sapiens)
TP63 - P1308L (1)
Pain Link Frequency Relevance Heat
psoriasis 55 96.96 Very High Very High Very High
Inflammation 36 96.12 Very High Very High Very High
Paroxysmal extreme pain disorder 32 67.04 Quite High
Etanercept 17 57.56 Quite High
antagonist 1 52.20 Quite High
sodium channel 9 51.84 Quite High
Pain 19 50.00 Quite Low
cytokine 20 46.92 Quite Low
addiction 3 40.48 Quite Low
chemokine 2 32.80 Quite Low
Disease Link Frequency Relevance Heat
Psoriasis 68 99.50 Very High Very High Very High
INFLAMMATION 36 96.12 Very High Very High Very High
Erythermalgia 31 83.20 Quite High
Disease 32 75.92 Quite High
Somatoform Disorder 32 67.04 Quite High
Pain 21 50.00 Quite Low
Skin Diseases 3 19.24 Low Low
Ganglion Cysts 33 5.00 Very Low Very Low Very Low
Infection 25 5.00 Very Low Very Low Very Low
Demyelinating Disease 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In humans, IL-23 is clearly elevated in psoriatic lesions as indicated by increased levels of both p19 and p40 (subunits of IL-23) mRNA in lesional skin as compared to non-lesional skin, but the mRNA levels of p35 (subunit of IL-12) are not.30 These data suggest that IL-23 appears to play a more dominant role than IL-12 in psoriasis.
Positive_regulation (increased) of Positive_regulation (increased) of p40 in skin associated with psoriasis
1) Confidence 0.05 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857612 Disease Relevance 1.01 Pain Relevance 0.40
The faster inactivation kinetics of P1308L may be due to enhanced activation of P1308L channels, since open-state fast-inactivation is coupled to the activation state of channels [27].
Positive_regulation (enhanced) of Positive_regulation (activation) of P1308L (P1308L)
2) Confidence 0.03 Published 2010 Journal Mol Pain Section Body Doc Link PMC2876140 Disease Relevance 0.15 Pain Relevance 0.09

General Comments

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