INT307219

Context Info Confidence 0.07 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.12 Pain Relevance 0

DNA binding (Mlxipl, Srebf1) cytoplasm (Mlxipl, Srebf1) nucleus (Mlxipl, Srebf1) Golgi apparatus (Srebf1) endoplasmic reticulum (Srebf1) protein complex (Srebf1)

Anatomy Link Frequency liver 1 Mlxipl (Mus musculus) Srebf1 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 18 50.00 Paracetamol 1 21.84 agonist 9 5.00 Inflammatory response 6 5.00 Kinase C 6 5.00 alcohol 3 5.00 cytokine 2 5.00 Central nervous system 1 5.00 ischemia 1 5.00 Bile 1 5.00

Disease Link Frequency Relevance Heat Obesity 13 66.44 Overweight 1 57.40 INFLAMMATION 24 50.00 Cancer 6 50.00 Hypolipidemia 1 50.00 Targeted Disruption 16 25.92 Hepatotoxicity 2 22.76 Liver Cancer 16 8.88 Stress 10 5.00 Disorder Of Lipid Metabolism 9 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In the liver, lipogenesis is regulated by transcription factors, sterol regulatory element-binding protein (SREBP-1c), carbohydrate response-element binding protein (ChREBP) and PPAR?

ChREBP Regulation (regulated) of SREBP-1c in liver

1) Confidence 0.07 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0.12 Pain Relevance 0

General Comments

This test has worked.