INT307222

Context Info Confidence 0.10 First Reported 2010 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.30 Pain Relevance 0

cytoplasm (CYLD, BCL3) structural constituent of ribosome (CYLD) ribosome (CYLD) intracellular (CYLD) protein binding, bridging (BCL3) extracellular matrix organization (BCL3)

CYLD (Homo sapiens) BCL3 (Homo sapiens)

Pain Link Frequency Relevance Heat cINOD 1 43.36 Inflammation 5 24.24 psoriasis 1 9.36 cytokine 2 5.00 Inflammatory mediators 1 5.00

Disease Link Frequency Relevance Heat Cholesteatoma 60 91.12 Hyperplasia 7 82.00 Apoptosis 12 50.48 INFLAMMATION 7 43.12 Colon Cancer 1 38.60 Hepatocellular Cancer 1 37.92 Carcinoma 1 36.56 Rheumatoid Arthritis 24 11.76 Psoriasis 1 9.36 Cancer 5 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In the present study, the cytoplasmic and perinuclear expression levels of CYLD suggest that CYLD may play a role in the deubiquitination of BCl-3 and/or TRAF in NF-?

CYLD Spec (may) Regulation (role) of Negative_regulation (deubiquitination) of BCl-3

1) Confidence 0.10 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2858283 Disease Relevance 0.30 Pain Relevance 0

General Comments

This test has worked.