INT307720

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Context Info
Confidence 0.68
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 14
Disease Relevance 14.69
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (PALLD) nucleus (PALLD) cytoskeleton organization (PALLD)
cytoplasm (PALLD)
Anatomy Link Frequency
pancreas 10
stroma 2
parenchymal cells 2
fibroblasts 2
epithelial cells 2
PALLD (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 14 92.24 High High
Chronic pancreatitis 28 86.36 High High
Disease Link Frequency Relevance Heat
Adenocarcinoma 616 100.00 Very High Very High Very High
Pancreatic Cancer 294 99.92 Very High Very High Very High
Cancer 1218 99.84 Very High Very High Very High
Breast Cancer 84 99.74 Very High Very High Very High
Disease Progression 28 99.68 Very High Very High Very High
Metastasis 224 99.40 Very High Very High Very High
Pancreatitis 98 96.88 Very High Very High Very High
Congenital Anomalies 14 96.32 Very High Very High Very High
Injury 42 95.12 Very High Very High Very High
Metaplasia 14 93.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, the results provide evidence that palladin is overexpressed specifically in pancreas tumors, yet the identity of the cell type that is responsible for upregulating palladin in these tumors remains unclear.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of palladin in pancreas associated with cancer
1) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2859948 Disease Relevance 1.04 Pain Relevance 0
Although the follow-up study confirmed that palladin is overexpressed in 96% of pancreas tumors as compared to normal pancreas, it showed that palladin is upregulated in stromal fibroblasts rather than in the neoplastic cells of pancreas tumors [6].
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of palladin in pancreas associated with cancer
2) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2859948 Disease Relevance 1.14 Pain Relevance 0
The 85–90 kDa palladin isoform is highly overexpressed in tumor-associated fibroblasts (TAFs) in both primary and metastatic tumors compared to normal pancreas, in samples obtained from either human patients or genetically engineered mice.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of palladin isoform in pancreas associated with cancer and metastasis
3) Confidence 0.68 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2859948 Disease Relevance 1.07 Pain Relevance 0
Palladin was found to be overexpressed in samples of sporadic pancreatic adenocarcinoma and in tumor-derived cell lines [5].
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of Palladin associated with adenocarcinoma and cancer
4) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2859948 Disease Relevance 1.18 Pain Relevance 0
Also, our results are in good agreement with a previous analysis of palladin expression that was achieved by staining of a tumor microarray, in which palladin was found to be overexpressed in >96% of pancreatic adenocarcinomas [6].
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of palladin associated with adenocarcinoma and cancer
5) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2859948 Disease Relevance 0.85 Pain Relevance 0
Recently, the actin-associated protein palladin was identified as a candidate biomarker when it was shown that palladin is mutated in a rare inherited form of PDA, and overexpressed in many sporadic pancreas tumors and premalignant precursors.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of palladin in pancreas associated with adenocarcinoma and cancer
6) Confidence 0.49 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2859948 Disease Relevance 1.01 Pain Relevance 0
Palladin-expressing fibroblasts increase in number and staining intensity with disease progression, as strongly positive TAFs were seen diffusely infiltrating the invasive ductal adenocarcinomas, along with occasional faint cytoplasmic staining of the primary tumor cells (Figure 5).
Positive_regulation (increase) of Gene_expression (expressing) of Palladin in fibroblasts associated with adenocarcinoma, cancer and disease progression
7) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2859948 Disease Relevance 1.23 Pain Relevance 0.04
Recently, the actin-associated protein palladin was identified as a candidate biomarker when it was shown that palladin is mutated in a rare inherited form of PDA, and overexpressed in many sporadic pancreas tumors and premalignant precursors.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of palladin in pancreas associated with adenocarcinoma and cancer
8) Confidence 0.49 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2859948 Disease Relevance 0.99 Pain Relevance 0
We note that the ductal epithelial cells in the adjacent PanINs do not show palladin expression, nor do the surrounding normal acinar parenchymal cells.
Neg (not) Positive_regulation (show) of Gene_expression (expression) of palladin in parenchymal cells
9) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2859948 Disease Relevance 1.24 Pain Relevance 0.05
Our IHC results are in agreement with an earlier study, which reported that palladin is strongly overexpressed in the stroma of 171 of 177 sections (96.6%) of PDA tumors [6].
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of palladin in stroma associated with adenocarcinoma and cancer
10) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2859948 Disease Relevance 0.86 Pain Relevance 0.09
We performed immunohistochemical analyses on primary tumors and metastases harvested from these mice to characterize palladin expression during disease progression.
Positive_regulation (characterize) of Gene_expression (expression) of palladin associated with cancer, disease progression and metastasis
11) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2859948 Disease Relevance 1.35 Pain Relevance 0.03
In human breast cancer cells, high levels of palladin expression are associated with increased invasiveness [15], [16], which suggests the possibility that abnormalities in palladin expression or function might contribute to the disregulated motility of metastatic cancer cells.
Positive_regulation (levels) of Gene_expression (expression) of palladin associated with congenital anomalies, breast cancer and metastasis
12) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2859948 Disease Relevance 1.32 Pain Relevance 0
We also show that palladin overexpression occurs primarily in tumor-associated fibroblasts (TAFs), and not the neoplastic epithelial cells, of human pancreatic tumors.
Positive_regulation (overexpression) of Gene_expression (overexpression) of palladin in epithelial cells associated with cancer and pancreatic cancer
13) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2859948 Disease Relevance 0.96 Pain Relevance 0
To extend our observations to samples collected by needle-core biopsy, we performed immunoblot analysis to determine the origin of cells within the patient samples that express high levels of 85–90 kDa palladin.
Positive_regulation (levels) of Gene_expression (express) of palladin
14) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2859948 Disease Relevance 0.47 Pain Relevance 0

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