INT308701

Context Info Confidence 0.15 First Reported 2010 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 1 Total Number 3 Disease Relevance 3.53 Pain Relevance 0.32

transport (AQP4) helicase activity (DDX41) transmembrane transport (AQP4) cytoplasm (AQP4) RNA binding (DDX41) nucleolus (DDX41)

Anatomy Link Frequency M-1 1 AQP4 (Homo sapiens) DDX41 (Homo sapiens)

Pain Link Frequency Relevance Heat Multiple sclerosis 42 94.12 Neuritis 33 93.00 Demyelination 21 55.16 Central nervous system 12 5.00 Sicca syndrome 9 5.00 headache 6 5.00 Spinal cord 3 5.00 Analgesic 3 5.00 Inflammation 3 5.00 Sciatica 3 5.00

Disease Link Frequency Relevance Heat Neuromyelitis Optica 282 100.00 Disease 42 97.72 Neurological Disease 27 94.44 Demyelinating Disease 78 94.12 Optic Neuritis 30 93.00 Systemic Lupus Erythematosus 45 87.00 Recurrence 18 77.88 Syndrome 42 55.16 Transverse Myelitis 27 5.00 Headache 6 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Our results suggest M-23 AQP4 as initial and major target antigen for antibody binding in definite and high risk NMO patients, whereas Abs to M-1 AQP4 are predominantly developed with increasing disease duration and severity.

AQP4 Binding (binding) of Abs in M-1 associated with neuromyelitis optica and disease

1) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864757 Disease Relevance 1.13 Pain Relevance 0.13

In comparison to AQP4-IgG, AQP4-IgM Abs are not a reliable biomarker, although they were elevated in definite and high risk NMO patients.

AQP4-IgG Neg (not) Binding (biomarker) of Abs associated with neuromyelitis optica

2) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864757 Disease Relevance 1.17 Pain Relevance 0.14

NMO-Ig Abs resulted in different staining patterns when binding to full length AQP4 in contrast to the M-23 AQP4 isoform.

AQP4 Binding (binding) of Abs associated with neuromyelitis optica

3) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864757 Disease Relevance 1.22 Pain Relevance 0.06

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