INT308703

Context Info Confidence 0.08 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.61 Pain Relevance 0

transport (AQP4) plasma membrane (AQP4) transmembrane transport (AQP4) cytoplasm (AQP4)

Anatomy Link Frequency M-1 2 AQP4 (Homo sapiens) M1 (Homo sapiens)

Pain Link Frequency Relevance Heat Multiple sclerosis 14 23.00 Demyelination 7 16.08 Neuritis 11 5.00 Central nervous system 4 5.00 Sicca syndrome 3 5.00 headache 2 5.00 Spinal cord 1 5.00 Analgesic 1 5.00 Inflammation 1 5.00 Sciatica 1 5.00

Disease Link Frequency Relevance Heat Neuromyelitis Optica 94 95.44 Disease 14 93.52 Demyelinating Disease 26 48.72 Systemic Lupus Erythematosus 15 47.92 Neurological Disease 9 23.20 Recurrence 6 19.44 Syndrome 14 16.08 Optic Neuritis 10 5.00 Transverse Myelitis 9 5.00 Headache 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Moreover, none of the patients were only positive for M-1 AQP4-IgG and negative for M-23 AQP4-IgG, or had higher titer levels for full length AQP4.

Positive_regulation (positive) of AQP4-IgG Binding (negative) of M-1 in M-1

1) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864757 Disease Relevance 0.61 Pain Relevance 0

General Comments

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