INT308731

Context Info Confidence 0.62 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 3 Disease Relevance 0 Pain Relevance 0

endosome (Cftr) transport (Cftr) ATPase activity (Cftr) enzyme binding (Cftr) protein complex (Cftr) transmembrane transport (Cftr)

Cftr (Mus musculus)

Pain Link Frequency Relevance Heat fibrosis 96 14.24 Inflammation 9 5.00 abdominal pain 3 5.00

Disease Link Frequency Relevance Heat Leukemia 3 45.56 Cystic Fibrosis 96 14.24 Disorder Of Lipid Metabolism 36 5.00 Congenital Anomalies 18 5.00 Infection 18 5.00 INFLAMMATION 9 5.00 Steatorrhea 6 5.00 Appetite Loss 6 5.00 Exocrine Pancreatic Insufficiency 6 5.00 Disease 6 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

1000 anti-CFTR, acetyl-CoA carboxylase (ACC), AMP-activated protein kinase (AMPK), phosphorylated ACC or phosphorylated AMPK (Cell Signaling, Danvers, MA) or 1?

Phosphorylation (phosphorylated) of CFTR

1) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864762 Disease Relevance 0 Pain Relevance 0

1000 anti-CFTR, acetyl-CoA carboxylase (ACC), AMP-activated protein kinase (AMPK), phosphorylated ACC or phosphorylated AMPK (Cell Signaling, Danvers, MA) or 1?

Phosphorylation (phosphorylated) of CFTR

2) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864762 Disease Relevance 0 Pain Relevance 0

In line with the enhanced lipogenesis and the decreased phosphorylation state of ACC, CFTR knockdown resulted in a significant increase in SREBP-1c gene expression (Figure 10).

Phosphorylation (phosphorylation) of CFTR

3) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864762 Disease Relevance 0 Pain Relevance 0

General Comments

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